Use of In Situ Atomic Force Microscopy to Follow Phase Changes at Crystal Surfaces in Real Time

被引：39

作者：

Thakuria, Ranjit ^{[1
,5
]}

Eddleston, Mark D. ^{[1
]}

Chow, Ernest H. H. ^{[1
]}

Lloyd, Gareth O. ^{[1
]}

Aldous, Barry J. ^{[2
]}

Krzyzaniak, Joseph F. ^{[3
]}

Bond, Andrew D. ^{[4
]}

Jones, William ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

[3] Pfizer Inc, Groton, CT 06340 USA

[4] Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark

[5] Tezpur Univ, Dept Chem Sci, Tezpur 784028, Assam, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 40期

关键词：

atomic force microscopy; cocrystals; phase transitions; polymorphism; surface analysis; MECHANICAL-PROPERTIES; POLYMORPHS; DISSOLUTION; PREDICTION; COCRYSTALS; DISCRIMINATION; TRANSFORMATION; ASPIRIN;

D O I：

10.1002/anie.201302532

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AFM of cocrystals: Atomic force microscopy can be used to observe phase changes at crystal surfaces where the transformation is accompanied by a change in the spacing between layers of molecules (see picture). The conversion of a metastable polymorph of the caffeine-glutaric acid cocrystal into the thermodynamically stable form was analyzed continuously in situ using intermittent-contact-mode atomic force microscopy. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10541 / 10544

页数：4

共 34 条

[1] Dissolution on cholesterol monohydrate single-crystal surfaces monitored by in situ atomic force microscopy [J].

Abendan, RS ;

Swift, JA .

CRYSTAL GROWTH & DESIGN, 2005, 5 (06) :2146-2153

[2] Polymorphs and Solvates of a Cocrystal Involving an Analgesic Drug, Ethenzamide, and 3,5-Dinitrobenzoic Acid [J].

Aitipamula, Srinivasulu ;

Chow, Pui Shan ;

Tan, Reginald B. H. .

CRYSTAL GROWTH & DESIGN, 2010, 10 (05) :2229-2238

[3] The prediction, morphology, and mechanical properties of the polymorphs of paracetamol [J].

Beyer, T ;

Day, GM ;

Price, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (21) :5086-5094

[4] ATOMIC FORCE MICROSCOPE [J].

BINNIG, G ;

QUATE, CF ;

GERBER, C .

PHYSICAL REVIEW LETTERS, 1986, 56 (09) :930-933

[5] ATOMIC RESOLUTION WITH ATOMIC FORCE MICROSCOPE [J].

BINNIG, G ;

GERBER, C ;

STOLL, E ;

ALBRECHT, TR ;

QUATE, CF .

EUROPHYSICS LETTERS, 1987, 3 (12) :1281-1286

[6]

Brittain H.G., 2009, Polymorphism in Pharmaceutical Solids

[7] Correlating Particle Hardness With Powder Compaction Performance [J].

Cao, Xiaoping ;

Morganti, Mikayla ;

Hancock, Bruno C. ;

Masterson, Victoria M. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (10) :4307-4316

[8] Following the surface response of caffeine cocrystals to controlled humidity storage by atomic force microscopy [J].

Cassidy, A. M. C. ;

Gardner, C. E. ;

Jones, W. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 379 (01) :59-66

[9] New opportunities in crystal engineering - the role of atomic force microscopy in studies of molecular crystals [J].

Chow, Ernest H. H. ;

Bucar, Dejan-Kresimir ;

Jones, William .

CHEMICAL COMMUNICATIONS, 2012, 48 (74) :9210-9226

[10] Screw dislocations on polycenes: A requirement for crystallization [J].

Cuppen, HM ;

Graswincke, WS ;

Meekes, H .

CRYSTAL GROWTH & DESIGN, 2004, 4 (06) :1351-1357

← 1 2 3 4 →