Solid-phase synthesis of palmitoylated and farnesylated lipopeptides employing the fluoride-labile PTMSEL linker

被引：7
|
作者：
Lumbierres, M
Palomo, JM
Kragol, G
Waldmann, H
机构：
[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany
[2] Univ Dortmund, Fachbereich 3, D-44221 Dortmund, Germany
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 16期
关键词：
lipopeptides; solid-phase synthesis; linker groups; Ras protein;
D O I：
10.1016/j.tetlet.2006.02.109
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Acid- and base-labile S-palmitoylated and S-farnesylated lipopeptides can be synthesized in high overall yield employing the (2-phenyl-2-trimethylsilyl) ethyl (PTMSEL) linker for anchoring to and release under almost neutral conditions from the solid Support. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2671 / 2674
页数：4
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