Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D-1A-deficient mouse

被引:66
作者
Crawford, CA
Drago, J
Watson, JB
Levine, MS
机构
[1] CALIF STATE UNIV SAN BERNARDINO,DEPT PSYCHOL,SAN BERNARDINO,CA 92407
[2] MONASH UNIV,DEPT ANAT,CLAYTON,VIC 3168,AUSTRALIA
关键词
amphetamine; behavioral sensitization; dopamine receptor; protein kinase A;
D O I
10.1097/00001756-199707280-00021
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE role of dopamine D-1A receptors in mediating amphetamine-induced sensitization was investigated using the D-1A-deficient mouse. During the drug preexposure phase, D-1A-deficient and control mice were injected for five consecutive days with saline or amphetamine (2 mg/kg, i.p.). Locomotor activity was measured on the first and fifth pre-exposure day. After three abstinence days, mice were given either amphetamine or saline and locomotor activity was again assessed. Mice were then sacrificed and protein kinase A (PKA) activity was measured. In contrast to control mice, D-1A-deficient mice did not show a progressive increase in locomotor activity across days. Importantly, both control and mutant mice did exhibit behavioral sensitization, because mice pre-exposed and tested with amphetamine were more active than mice acutely tested with the drug. Even so, the amphetamine-induced locomotor activity of the mutant mice was significantly reduced when compared with similarly treated control mice, indicating that the sensitized response was less pronounced in the D-1A-deficient mouse. PKA activity also varied depending on genotype, since amphetamine decreased PKA activity in control but not D-1A-deficient mice.
引用
收藏
页码:2523 / 2527
页数:5
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