RETRACTED: MicroRNA MiR-214 Regulates Ovarian Cancer Cell Stemness by Targeting p53/Nanog (Retracted Article)

被引：102

作者：

Xu, Cheng-Xiong ^{[1
]}

Xu, Meng ^{[1
]}

Tan, Lei ^{[1
]}

Yang, Hua ^{[1
]}

Permuth-Wey, Jennifer ^{[2
]}

Kruk, Patricia A. ^{[4
]}

Wenham, Robert M. ^{[3
]}

Nicosia, Santo V. ^{[3
,4
]}

Lancaster, Johnathan M. ^{[3
]}

Sellers, Thomas A. ^{[2
]}

Cheng, Jin Q. ^{[1
,4
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Mol Oncol, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA

[3] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Gynecol Oncol, Tampa, FL 33612 USA

[4] Univ S Florida, Morsani Coll Med, Dept Pathol & Cell Biol, Tampa, FL USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 42期

关键词：

BREAST-CANCER; EXPRESSION SIGNATURE; DOWN-REGULATION; HUMAN TUMORS; P53; NANOG; RESISTANCE; DIFFERENTIATION; CHEMOTHERAPY; RECOGNITION;

D O I：

10.1074/jbc.M112.374611

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have shown aberrant expression of miR-214 in human malignancy. Elevated miR-214 is associated with chemoresistance and metastasis. In this study, we identified miR-214 regulation of ovarian cancer stem cell (OCSC) properties by targeting p53/Nanog axis. Enforcing expression of miR-214 increases, whereas knockdown of miR-214 decreases, OCSC population and self-renewal as well as the Nanog level preferentially in wild-type p53 cell lines. Furthermore, we found that p53 is directly repressed by miR-214 and that miR-214 regulates Nanog through p53. Expression of p53 abrogated miR-214-induced OCSC properties. These data suggest the critical role of miR-214 in OCSC via regulation of the p53-Nanog axis and miR-214 as a therapeutic target for ovarian cancer.

引用

页码：34970 / 34978

页数：9

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