RETRACTED: MicroRNA MiR-214 Regulates Ovarian Cancer Cell Stemness by Targeting p53/Nanog (Retracted Article)

被引：102
|
作者：
Xu, Cheng-Xiong [1 ]
Xu, Meng [1 ]
Tan, Lei [1 ]
Yang, Hua [1 ]
Permuth-Wey, Jennifer [2 ]
Kruk, Patricia A. [4 ]
Wenham, Robert M. [3 ]
Nicosia, Santo V. [3 ,4 ]
Lancaster, Johnathan M. [3 ]
Sellers, Thomas A. [2 ]
Cheng, Jin Q. [1 ,4 ]
机构：
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Mol Oncol, Tampa, FL 33612 USA
[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA
[3] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Gynecol Oncol, Tampa, FL 33612 USA
[4] Univ S Florida, Morsani Coll Med, Dept Pathol & Cell Biol, Tampa, FL USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 42期
关键词：
BREAST-CANCER; EXPRESSION SIGNATURE; DOWN-REGULATION; HUMAN TUMORS; P53; NANOG; RESISTANCE; DIFFERENTIATION; CHEMOTHERAPY; RECOGNITION;
D O I：
10.1074/jbc.M112.374611
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous studies have shown aberrant expression of miR-214 in human malignancy. Elevated miR-214 is associated with chemoresistance and metastasis. In this study, we identified miR-214 regulation of ovarian cancer stem cell (OCSC) properties by targeting p53/Nanog axis. Enforcing expression of miR-214 increases, whereas knockdown of miR-214 decreases, OCSC population and self-renewal as well as the Nanog level preferentially in wild-type p53 cell lines. Furthermore, we found that p53 is directly repressed by miR-214 and that miR-214 regulates Nanog through p53. Expression of p53 abrogated miR-214-induced OCSC properties. These data suggest the critical role of miR-214 in OCSC via regulation of the p53-Nanog axis and miR-214 as a therapeutic target for ovarian cancer.
引用
收藏
页码：34970 / 34978
页数：9
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