Assessing T-cell responses in anticancer immunotherapy Dendritic cells or myeloid-derived suppressor cells?

被引：18

作者：

Escors, David ^{[1
,2
]}

Liechtenstein, Therese ^{[1
]}

Perez-Janices, Noemi ^{[1
,2
]}

Schwarze, Julia ^{[3
]}

Dufait, Ines ^{[3
]}

Goyvaerts, Cleo ^{[3
]}

Lanna, Alessio ^{[1
]}

Arce, Frederick ^{[4
]}

Blanco-Luquin, Idoia ^{[2
]}

Kochan, Grazyna ^{[2
]}

Guerrero-Setas, David ^{[2
]}

Breckpot, Karine ^{[3
]}

机构：

[1] UCL, Rayne Inst, London, England

[2] Complejo Hosp Navarra, Navarrabiomed Fdn Miguel Servet, Pamplona, Spain

[3] Vrije Univ Brussel, Brussels, Belgium

[4] UCL, Paul OGorman Inst, London, England

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 10期

关键词：

antigen presentation; cancer; dendritic cells; myeloid-derived suppressor cell; T cells; GM-CSF; TUMOR LYSATE; CO-STIMULATION; ANTIGEN; CANCER; ACTIVATION; DIFFERENTIATION; MELANOMA; VIRUS; MODULATION;

D O I：

10.4161/onci.26148

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since dendritic cells operate as professional antigen-presenting cells (APCs) and hence are capable of jumpstarting the immune system, they have been exploited to develop a variety of immunotherapeutic regimens against cancer. In the few past years, myeloid-derived suppressor cells (MDSCs) have been shown to mediate robust immunosuppressive functions, thereby inhibiting tumor-targeting immune responses. Thus, we propose that the immunomodulatory activity of MDSCs should be carefully considered for the development of efficient anticancer immunotherapies.

引用

页数：9

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