Assessing T-cell responses in anticancer immunotherapy Dendritic cells or myeloid-derived suppressor cells?

被引：18

作者：

Escors, David ^{[1
,2
]}

Liechtenstein, Therese ^{[1
]}

Perez-Janices, Noemi ^{[1
,2
]}

Schwarze, Julia ^{[3
]}

Dufait, Ines ^{[3
]}

Goyvaerts, Cleo ^{[3
]}

Lanna, Alessio ^{[1
]}

Arce, Frederick ^{[4
]}

Blanco-Luquin, Idoia ^{[2
]}

Kochan, Grazyna ^{[2
]}

Guerrero-Setas, David ^{[2
]}

Breckpot, Karine ^{[3
]}

机构：

[1] UCL, Rayne Inst, London, England

[2] Complejo Hosp Navarra, Navarrabiomed Fdn Miguel Servet, Pamplona, Spain

[3] Vrije Univ Brussel, Brussels, Belgium

[4] UCL, Paul OGorman Inst, London, England

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 10期

关键词：

antigen presentation; cancer; dendritic cells; myeloid-derived suppressor cell; T cells; GM-CSF; TUMOR LYSATE; CO-STIMULATION; ANTIGEN; CANCER; ACTIVATION; DIFFERENTIATION; MELANOMA; VIRUS; MODULATION;

D O I：

10.4161/onci.26148

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since dendritic cells operate as professional antigen-presenting cells (APCs) and hence are capable of jumpstarting the immune system, they have been exploited to develop a variety of immunotherapeutic regimens against cancer. In the few past years, myeloid-derived suppressor cells (MDSCs) have been shown to mediate robust immunosuppressive functions, thereby inhibiting tumor-targeting immune responses. Thus, we propose that the immunomodulatory activity of MDSCs should be carefully considered for the development of efficient anticancer immunotherapies.

引用

页数：9

共 82 条

[1] Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses [J].

Abdel-Wahab, Z ;

Cisco, R ;

Dannull, J ;

Ueno, T ;

Abdel-Wahab, O ;

Kalady, MF ;

Onaitis, MW ;

Tyler, DS ;

Pruitt, SK .

JOURNAL OF SURGICAL RESEARCH, 2005, 124 (02) :264-273

[2] Tumor immunotherapy using bone marrow-derived dendritic cells overexpressing Toll-like receptor adaptors [J].

Akazawa, Takashi ;

Shingai, Masashi ;

Sasai, Mwa ;

Ebihara, Takashi ;

Inoue, Norimitsu ;

Matsumoto, Misako ;

Seya, Tsukasa .

FEBS LETTERS, 2007, 581 (18) :3334-3340

[3] Immortalized myeloid suppressor cells trigger apoptosis in antigen-activated T lymphocytes [J].

Apolloni, E ;

Bronte, V ;

Mazzoni, A ;

Serafini, P ;

Cabrelle, A ;

Segal, DM ;

Young, HA ;

Zanovello, P .

JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :6723-6730

[4] Selective Activation of Intracellular Signalling Pathways in Dendritic Cells for Cancer Immunotherapy [J].

Arce, Frederick ;

Kochan, Grazyna ;

Breckpot, Karine ;

Stephenson, Holly ;

Escors, David .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2012, 12 (01) :29-39

[5] Selective ERK Activation Differentiates Mouse and Human Tolerogenic Dendritic Cells, Expands Antigen-Specific Regulatory T Cells, and Suppresses Experimental Inflammatory Arthritis [J].

Arce, Frederick ;

Breckpot, Karine ;

Stephenson, Holly ;

Karwacz, Katarzyna ;

Ehrenstein, Michael R. ;

Collins, Mary ;

Escors, David .

ARTHRITIS AND RHEUMATISM, 2011, 63 (01) :84-95

[6] Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells [J].

Arrighi, JF ;

Pion, M ;

Wiznerowicz, M ;

Geijtenbeek, TB ;

Garcia, E ;

Abraham, S ;

Leuba, F ;

Dutoit, V ;

Ducrey-Rundquist, O ;

van Kooyk, Y ;

Trono, D ;

Piguet, V .

JOURNAL OF VIROLOGY, 2004, 78 (20) :10848-10855

[7] Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA [J].

Bonehill, Aude ;

Tuyaerts, Sandra ;

Van Nuffel, An Mt ;

Heirman, Carlo ;

Bos, Tomas J. ;

Fostier, Karel ;

Neyns, Bart ;

Thielemans, Kris .

MOLECULAR THERAPY, 2008, 16 (06) :1170-1180

[8]

Breckpot Karine, 2009, Endocrine Metabolic & Immune Disorders-Drug Targets, V9, P328

[9] Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine [J].

Breckpot, Karine ;

Aerts-Toegaert, Cindy ;

Heirman, Carlo ;

Peeters, Uschi ;

Beyaert, Rudi ;

Aerts, Joeri L. ;

Thielemans, Kris .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :860-870

[10] Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+ T cells [J].

Bronte, V ;

Apolloni, E ;

Cabrelle, A ;

Ronca, R ;

Serafini, P ;

Zamboni, P ;

Restifo, NP ;

Zanovello, P .

BLOOD, 2000, 96 (12) :3838-3846

← 1 2 3 4 5 6 7 8 9 →