Fluorinated Compounds Against Mycobacterium tuberculosis

被引：8
|
作者：
Boechat, Nubia [1 ]
Bastos, Monica M. [1 ]
机构：
[1] Fiocruz MS, Inst Tecnol Farmacos Farmanguinhos, Dept Sintese Farmacos, BR-21041250 Rio De Janeiro, RJ, Brazil
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 22期
关键词：
Organofluorine; fluoroquinolones; trifluoromethyl; nitroimidazoles; N-fluorobenzoxazolidinones; Mycobacterium tuberculosis; IN-VITRO ANTIMYCOBACTERIAL; MULTIDRUG-RESISTANT; ANTITUBERCULOSIS ACTIVITY; QUINOXALINE 1,4-DIOXIDES; BACTERICIDAL ACTIVITY; POTENTIAL TREATMENT; DERIVATIVES; ANALOGS; DRUG; ANTIBACTERIAL;
D O I：
10.2174/15680266113136660204
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Tuberculosis is a severe infectious disease currently being treated with drugs that were developed more than 40 years ago. In recent years, the emergence of resistant Mycobacterium tuberculosis strains, as well as co-infection with the AIDS virus, has caused global concern about the evolution of the disease. Thus, the search for new drugs has become a necessity and a great challenge. Fluorine is a strategic element that is very useful in medicinal chemistry for its great influence on the biological activity of substances. This review highlights the importance of fluorinated molecules that are currently in clinical use or pre-clinical phases of development. Further, some substances in the prototype development stage are cited, which potentially represent future alternatives for the treatment of tuberculosis.
引用
收藏
页码：2885 / 2904
页数：20
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