Synthesis and antidepressant evaluation of three para-benzoquinone mono-oximes and their oxy derivatives

被引：30

作者：

de Sousa, DP ^{[1
]}

Schefer, RR ^{[1
]}

Brocksom, U ^{[1
]}

Brocksom, TJ ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Quim, Lab Quim Bioorgan, BR-13565905 Sao Carlos, SP, Brazil

来源：

MOLECULES | 2006年 / 11卷 / 2-3期

关键词：

oximes; para-benzoquinones; antidepressant activity;

D O I：

10.3390/11020148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.

引用

页码：148 / 155

页数：8

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