New approach to fully automated synthesis of sodium [18F]fluoroacetate -: a simple and fast method using a commercial synthesizer

被引：25

作者：

Sun, LQ

Mori, T

Dence, CS

Ponde, DE

Welch, MJ

Furukawa, T

Yonekura, Y

Fujibayashi, Y ^{[1
]}

机构：

[1] Univ Fukui, Biomed Imaging Res Ctr, Fukui 9101193, Japan

[2] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, Div Radiol Sci, St Louis, MO 63110 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2006年 / 33卷 / 01期

基金：

日本学术振兴会;

关键词：

sodium [F-18]fluoroacetate; ethyl [F-18]fluoroacetate; automated synthesis; commercial synthesizer; PET tracer;

D O I：

10.1016/j.nucmedbio.2005.07.005

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A simple, rapid and fully automated preparation of sodium [F-18]fluoroacetate has been developed by taking advantage of the similarities between the reaction pathways of [F-18]fluoroacetate and [F-18]-2-fluoro-deoxyglucose (FDG). The automated synthesis of sodium [F-18]fluoroacetate was achieved with a commercial [F-18]FDG synthesizer, the TRACERlab MXFDG. The method produced the desired compound in a short synthesis time (32 min) and with a high and reproducible radiochemical yield (50.2 +/- 4.8%, decay corrected). The radiochemical purity of sodium [F-18]fluoroacetate was greater than 99%. (c) 2006 Published by Elsevier Inc.

引用

页码：153 / 158

页数：6

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