Blood microRNAs in Low or No Risk Ischemic Stroke Patients

被引：56

作者：

Tan, Jun Rong ^{[1
,2
]}

Tan, Kay Sin ^{[3
]}

Koo, Yu Xuan ^{[1
,2
]}

Yong, Fung Lin ^{[3
]}

Wang, Chee Woon ^{[4
]}

Armugam, Arunmozhiarasi ^{[1
,2
]}

Jeyaseelan, Kandiah ^{[1
,2
,5
]}

机构：

[1] Natl Univ Singapore, Dept Biochem, Singapore 117597, Singapore

[2] Natl Univ Singapore, Neurosci Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore 117597, Singapore

[3] Univ Malaya, Dept Med, Fac Med, Kuala Lumpur 50603, Malaysia

[4] MAHSA Univ Coll, Dept Biochem, Fac Med, Kuala Lumpur 59100, Malaysia

[5] Monash Univ, Fac Med Nursing & Hlth Sci, Dept Anat & Dev Biol, Sch Biomed Sci, Clayton, Vic 3800, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 01期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

stroke; microRNA; etiology; modified Rankin Score; TRANSIENT FOCAL ISCHEMIA; PERIPHERAL-BLOOD; GENE-EXPRESSION; CELL-SURVIVAL; PPAR-ALPHA; CANCER; BRAIN; PROLIFERATION; BIOMARKERS; SIGNATURES;

D O I：

10.3390/ijms14012072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ischemic stroke is a multi-factorial disease where some patients present themselves with little or no risk factors. Blood microRNA expression profiles are becoming useful in the diagnosis and prognosis of human diseases. We therefore investigated the blood microRNA profiles in young stroke patients who presented with minimal or absence of risk factors for stroke such as type 2 diabetes, dyslipidemia and hypertension. Blood microRNA profiles from these patients varied with stroke subtypes as well as different functional outcomes (based on modified Rankin Score). These microRNAs have been shown to target genes that are involved in stroke pathogenesis. The findings from our study suggest that molecular mechanisms in stroke pathogenesis involving low or no risk ischemic stroke patients could differ substantially from those with pre-existing risk factors.

引用

页码：2072 / 2084

页数：13

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