Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

被引：21

作者：

Mourao, Aline Mansueto ^{[1
,2
,3
]}

Caseiro Vicente, Laelia Cristina ^{[3
]}

Silva Abreu, Mery Natali ^{[4
]}

Sant'Anna, Romeu Vale ^{[1
]}

Marciano Vieira, Erica Leandro ^{[5
]}

de Souza, Leonardo Cruz ^{[5
]}

de Miranda, Aline Silva ^{[5
]}

Rachid, Milene Alvarenga ^{[5
]}

Teixeira, Antonio Lucio ^{[5
]}

机构：

[1] Univ Fed Minas Gerais, BR-31170220 Belo Horizonte, MG, Brazil

[2] Risoleta Tolentino Neves Hosp, Sect Stroke Unit, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Speech Therapy, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Dept Appl Nursing, Belo Horizonte, MG, Brazil

[5] Univ Minas Gerais UFMG, Sch Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2019年 / 28卷 / 03期

关键词：

Brain-derived neurotrophic factor; biomarker; stroke; ichemic stroke; stroke outcome; prognosis; BDNF; BIOMARKERS; BLOOD; GROWTH;

D O I：

10.1016/j.jstrokecerebrovasdis.2018.11.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.

引用

页码：735 / 740

页数：6

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