DEVELOPMENT, PRODUCTION AND CHARACTERIZATION OF NANOCRYSTALS OF POORLY SOLUBLE DRUGS

被引：3
作者：
Fangueiro, Joana F. [1 ]
Marques, Ines R. [1 ]
Severino, Patricia [1 ,2 ]
Santana, Maria Helena A. [2 ]
Souto, Eliana B. [1 ,3 ]
机构：
[1] Univ Fernando Pessoa, Fac Ciencias Saude, P-4200150 Oporto, Portugal
[2] Univ Estadual Campinas, Fac Engn Quim, Dept Proc Biotecnol, BR-13083852 Campinas, SP, Brazil
[3] Univ Tras Os Montes & Alto Douro, Inst Biotecnol & Bioengn, Ctr Genom & Biotecnol, P-5001801 Vila Real, Portugal
来源：
QUIMICA NOVA | 2012年 / 35卷 / 09期
关键词：
nancrystals; microfluidization; high pressure homogenization; PHARMACOKINETIC EVALUATION; LIPID NANOPARTICLES; PARTICLE-SIZE; NANOSUSPENSION; FORMULATION; TECHNOLOGY; STABILITY; BIOAVAILABILITY; ITRACONAZOLE; IMPROVEMENT;
D O I：
10.1590/S0100-40422012000900025
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DEVELOPMENT, PRODUCTION AND CHARACTERIZATION OF NANOCRYSTALS OF POORLY SOLUBLE DRUGS. Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.
引用
收藏
页码：1848 / 1853
页数：6
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