Pharmacokinetic problems in clinical practice - role of drug transporters

被引:6
作者
Rosskopf, D. [1 ]
Kroemer, H. K. [1 ]
Siegmund, W. [2 ]
机构
[1] Ernst Moritz Arndt Univ Greifswald, Inst Pharmakol, Abt Allgemeine Pharmakol, D-17485 Greifswald, Germany
[2] Ernst Moritz Arndt Univ Greifswald, Inst Pharmakol, Klin Pharmakol Abt, D-17485 Greifswald, Germany
关键词
drug interactions; drug transport; drug metabolism; CYP enzymes; ABC-transporter; SLCO1B1; ST-JOHNS-WORT; INTESTINAL P-GLYCOPROTEIN; ORAL BIOAVAILABILITY; GRAPEFRUIT JUICE; TALINOLOL; DIGOXIN; DISPOSITION; INDUCTION; ABC; INHIBITION;
D O I
10.1055/s-0028-1124005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:345 / 356
页数:12
相关论文
共 34 条
  • [21] Link E, 2008, NEW ENGL J MED, V359, P789, DOI 10.1056/NEJMoa0801936
  • [22] Structure and function of ABC transporters
    Linton, Kenneth J.
    [J]. PHYSIOLOGY, 2007, 22 : 122 - 130
  • [23] Mai I, 2000, INT J CLIN PHARM TH, V38, P500
  • [24] Concise review: Clinical relevance of drug-drug and herb-drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein)
    Marchetti, Serena
    Mazzanti, Roberto
    Beijnen, Jos H.
    Schellens, Jan H. M.
    [J]. ONCOLOGIST, 2007, 12 (08) : 927 - 941
  • [25] The role of coenzyme Q10 in statin-associated myopathy - A systematic review
    Marcoff, Leo
    Thompson, Paul D.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (23) : 2231 - 2237
  • [26] Clinical importance of the cytochromes P450
    Nebert, DW
    Russell, DW
    [J]. LANCET, 2002, 360 (9340) : 1155 - 1162
  • [27] Oral erythromycin and the risk of sudden death from cardiac causes
    Ray, WA
    Murray, KT
    Meredith, S
    Narasimhulu, SS
    Hall, K
    Stein, CM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (11) : 1089 - 1096
  • [28] Drug therapy: Drug-induced prolongation of the QT interval
    Roden, DM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (10) : 1013 - 1022
  • [29] Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception
    Schwarz, UI
    Büschel, B
    Kirch, W
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 55 (01) : 112 - 113
  • [30] Statin-associated myopathy
    Thompson, PD
    Clarkson, P
    Karas, RH
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (13): : 1681 - 1690