A systematic study towards evolutionary and epidemiological dynamics of currently predominant H5 highly pathogenic avian influenza viruses in Vietnam

被引：19

作者：

Lam Thanh Nguyen ^{[1
,2
]}

Firestone, Simon M. ^{[3
]}

Stevenson, Mark A. ^{[3
]}

Young, Neil D. ^{[3
]}

Sims, Leslie D. ^{[4
]}

Duc Huy Chu ^{[5
]}

Tien Ngoc Nguyen ^{[5
]}

Long Van Nguyen ^{[5
]}

Tung Thanh Le ^{[5
]}

Hung Van Nguyen ^{[5
]}

Hung Nam Nguyen ^{[5
]}

Tien Ngoc Tien ^{[6
]}

Tho Dang Nguyen ^{[7
]}

Bich Ngoc Tran ^{[2
]}

Matsuno, Keita ^{[1
,8
]}

Okamatsu, Masatoshi ^{[1
]}

Kida, Hiroshi ^{[8
,9
]}

Sakoda, Yoshihiro ^{[1
,8
]}

机构：

[1] Hokkaido Univ, Fac Vet Med, Lab Microbiol, Sapporo, Hokkaido 0600818, Japan

[2] Can Tho Univ, Coll Agr, Dept Vet Med, Can Tho, Vietnam

[3] Univ Melbourne, Fac Vet & Agr Sci, Melbourne Vet Sch, Parkville, Vic 3010, Australia

[4] Asia Pacific Vet Informat Serv, Montmorency, Vic 3094, Australia

[5] Minist Agr & Rural Dev, Dept & Subdept Anim Hlth, Hanoi, Vietnam

[6] Minist Agr & Rural Dev, Dept Anim Hlth, Reg Anim Hlth Off 7, Can Tho, Vietnam

[7] Minist Agr & Rural Dev, Dept Anim Hlth, Natl Ctr Vet Diagnost, Hanoi, Vietnam

[8] Hokkaido Univ, Global Inst Collaborat Res & Educ, Sapporo, Hokkaido 0010020, Japan

[9] Hokkaido Univ, Res Ctr Zoonosis Control, Sapporo, Hokkaido 0010020, Japan

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

基金：

日本学术振兴会; 澳大利亚研究理事会; 英国医学研究理事会;

关键词：

LIVE BIRD MARKETS; A(H5N1) VIRUS; POULTRY; DUCKS; INTERVENTION; VACCINATION; PREVALENCE; INFECTION; PATTERNS; CLADES;

D O I：

10.1038/s41598-019-42638-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study aimed to elucidate virus, host and environmental dynamics of Vietnamese H5 highly pathogenic avian influenza viruses (HPAIVs) during 2014-2017. Epidemiologically, H5 HPAIVs were frequently detected in apparently healthy domestic and Muscovy ducks and therefore these are preferred species for H5 HPAIV detection in active surveillance. Virologically, Glade 2.3.2.1c and 2.3.4.4 H5 HPAIVs were predominant and exhibited distinct phylogeographic evolution. Clade 2.3.2.1c viruses clustered phylogenetically in North, Central and South regions, whilst Glade 2.3.4.4 viruses only detected in North and Central regions formed small groups. These viruses underwent diverse reassortment with existence of at least 12 genotypes and retained typical avian-specific motifs. These H5 HPAIVs exhibited large antigenic distance from progenitor viruses and commercial vaccines currently used in poultry. Bayesian phylodynamic analysis inferred that Glade 2.3.2.1c viruses detected during 2014-2017 were likely descended from homologous Glade viruses imported to Vietnam previously and/or preexisting Chinese viruses during 2012-2013. Vietnamese Glade 2.3.4.4 viruses closely shared genetic traits with contemporary foreign spillovers, suggesting that there existed multiple transboundary virus dispersals to Vietnam. This study provides insights into the evolution of Vietnamese H5 HPAIVs and highlights the necessity of strengthening control measures such as, preventive surveillance and poultry vaccination.

引用

页数：13

共 53 条

[1]

[Anonymous], P GAT COMP ENV WORKS

[2]

[Anonymous], 2018, Cumulative number of confirmed human cases of avian influenza A(H5N1) reported to WHO

[3] Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China [J].

Bi, Yuhai ;

Chen, Quanjiao ;

Wang, Qianli ;

Chen, Jianjun ;

Jin, Tao ;

Wong, Gary ;

Quan, Chuansong ;

Liu, Jun ;

Wu, Jun ;

Yin, Renfu ;

Zhao, Lihua ;

Li, Mingxin ;

Ding, Zhuang ;

Zou, Rongrong ;

Xu, Wen ;

Li, Hong ;

Wang, Huijun ;

Tian, Kegong ;

Fu, Guanghua ;

Huang, Yu ;

Shestopalov, Alexander ;

Li, Shoujun ;

Xu, Bing ;

Yu, Hongjie ;

Luo, Tingrong ;

Lu, Lin ;

Xu, Xun ;

Luo, Yang ;

Liu, Yingxia ;

Shi, Weifeng ;

Liu, Di ;

Gao, George Fu .

Cell Host & Microbe, 2016, 20 (06) :810-821

[4] SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics [J].

Bielejec, Filip ;

Rambaut, Andrew ;

Suchard, Marc A. ;

Lemey, Philippe .

BIOINFORMATICS, 2011, 27 (20) :2910-2912

[5] Differences in Pathogenicity, Response to Vaccination, and Innate Immune Responses in Different Types of Ducks Infected with a Virulent H5N1 Highly Pathogenic Avian Influenza Virus from Vietnam [J].

Cagle, Caran ;

Wasilenko, Jamie ;

Adams, Sean C. ;

Cardona, Carol J. ;

Thanh Long To ;

Tung Nguyen ;

Spackman, Erica ;

Suarez, David L. ;

Smith, Diane ;

Shepherd, Eric ;

Roth, Jason ;

Pantin-Jackwood, Mary J. .

AVIAN DISEASES, 2012, 56 (03) :479-487

[6] Suboptimal protection against H5N1 highly pathogenic avian influenza viruses from Vietnam in ducks vaccinated with commercial poultry vaccines [J].

Cha, Ra Mi ;

Smith, Diane ;

Shepherd, Eric ;

Davis, C. Todd ;

Donis, Ruben ;

Tung Nguyen ;

Hoang Dang Nguyen ;

Do, Hoa Thi ;

Inui, Ken ;

Suarez, David L. ;

Swayne, David E. ;

Pantin-Jackwood, Mary .

VACCINE, 2013, 31 (43) :4953-4960

[7] A cross-sectional study to quantify the prevalence of avian influenza viruses in poultry at intervention and non-intervention live bird markets in central Vietnam, 2014 [J].

Chu, D. -H. ;

Stevenson, M. A. ;

Nguyen, L. V. ;

Isoda, N. ;

Firestone, S. M. ;

Nguyen, T. N. ;

Nguyen, L. T. ;

Matsuno, K. ;

Okamatsu, M. ;

Kida, H. ;

Sakoda, Y. .

TRANSBOUNDARY AND EMERGING DISEASES, 2017, 64 (06) :1991-1999

[8] Emergence of multiple clade 2.3.2.1 influenza A (H5N1) virus subgroups in Vietnam and detection of novel reassortants [J].

Creanga, Adrian ;

Diep Thi Nguyen ;

Gerloff, Nancy ;

Hoa Thi Do ;

Balish, Amanda ;

Hoang Dang Nguyen ;

Jang, Yunho ;

Vui Thi Dam ;

Thor, Sharmi ;

Jones, Joyce ;

Simpson, Natosha ;

Shu, Bo ;

Emery, Shannon ;

Berman, LaShondra ;

Nguyen, Ha T. ;

Bryant, Juliet E. ;

Lindstrom, Steve ;

Klimov, Alexander ;

Donis, Ruben O. ;

Davis, C. Todd ;

Tung Nguyen .

VIROLOGY, 2013, 444 (1-2) :12-20

[9] jModelTest 2: more models, new heuristics and parallel computing [J].

Darriba, Diego ;

Taboada, Guillermo L. ;

Doallo, Ramon ;

Posada, David .

NATURE METHODS, 2012, 9 (08) :772-772

[10] Economic factors influencing zoonotic disease dynamics: demand for poultry meat and seasonal transmission of avian influenza in Vietnam [J].

Delabouglise, Alexis ;

Choisy, Marc ;

Phan, Thang D. ;

Antoine-Moussiaux, Nicolas ;

Peyre, Marisa ;

Vu, Ton D. ;

Pfeiffer, Dirk U. ;

Fournie, Guillaume .

SCIENTIFIC REPORTS, 2017, 7

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