Catalytic Enantioselective Allylation of Ketimines by Using Palladium Pincer Complexes with Chiral Bis(imidazoline)s

被引：99

作者：

Nakamura, Shuichi ^{[1
]}

Hyodo, Kengo ^{[1
]}

Nakamura, Masayuki ^{[1
]}

Nakane, Daisuke ^{[1
]}

Masuda, Hideki ^{[1
]}

机构：

[1] Nagoya Inst Technol, Dept Frontier Mat, Grad Sch Engn, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 23期

关键词：

allylation; asymmetric catalysis; ketimines; palladium; pincer complexes; FRIEDEL-CRAFTS ALKYLATION; EFFECTIVE CORE POTENTIALS; PICTET-SPENGLER REACTIONS; ASYMMETRIC-SYNTHESIS; MOLECULAR CALCULATIONS; RECEPTOR ANTAGONISTS; MARINE ALKALOIDS; IMINES; ISATINS; AG-041R;

D O I：

10.1002/chem.201300685

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Get selective! Enantioselective allylation of ketimines derived from isatins by using chiral 1,3-bis(imidazolin-2-yl)benzene (Phebim)-PdII complexes afforded products with good enantioselectivity (see scheme). The reaction was applied to a wide variety of ketimines. The obtained product can be converted to homoallylic amines and a spirocyclic amine without the loss of enantiopurity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7304 / 7309

页数：6

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