NOPdb: Nucleolar Proteome Database-2008 update

被引：227

作者：

Ahmad, Yasmeen ^{[1
]}

Boisvert, Francois-Michel ^{[1
]}

Gregor, Peter ^{[2
]}

Cobley, Andy ^{[2
]}

Lamond, Angus I. ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

[2] Univ Dundee, Sch Comp, Dundee DD1 5EH, Scotland

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1093/nar/gkn804

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An experimental data handling system has been created as an update to the previous Nucleolar Proteome Database (NOPdb3.0: http://www.lamondlab.com/NOPdb3.0/). This updated system is able to manage large data sets identified by multiple mass spectrometry and has been used to analyse highly purified preparations of human nucleoli from different cell lines. The newly created application includes a dynamic relational database, which is kept up to date by laboratory staff. The data are further annotated with information from specific external sources on the web, including the IPI and Gene Ontology databases. In addition, an Application Programming Interface provides external users with a portal to link into the nucleolar proteome database and hence, gain access to continually updated results. From the initial similar to 700 human proteins identified in the previous iteration of the NOPdb, we have now identified over 50 000 peptides contained in over 4500 human proteins from purified nucleoli, providing enhanced coverage of the nucleolar proteome.

引用

页码：D181 / D184

页数：4

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