An unexpected friend - ROS in apoptosis-induced compensatory proliferation: Implications for regeneration and cancer

被引：109

作者：

Diwanji, Neha ^{[1
]}

Bergmann, Andreas ^{[1
]}

机构：

[1] Univ Massachusetts, Med Sch, Dept Mol Cell & Canc Biol, 364 Plantat St,LRB419, Worcester, MA 01605 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2018年 / 80卷

关键词：

Regeneration; Apoptosis-induced proliferation; Reactive oxygen species; Macrophages; Drosophila; CELLS STIMULATE PROLIFERATION; TUMOR-ASSOCIATED MACROPHAGES; DROSOPHILA IMAGINAL DISCS; MITOCHONDRIAL COMPLEX-III; HYDROGEN-PEROXIDE; CLEAVED CASPASE-3; OXIDATIVE STRESS; REDOX REGULATION; DAMAGE RESPONSE; WOUND REPAIR;

D O I：

10.1016/j.semcdb.2017.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Apoptosis-induced compensatory proliferation (AiP) is a form of compensatory proliferation that is triggered by apoptotic cell death to maintain tissue homeostasis. As such, AiP is essential for many tissue repair processes including regeneration. The apoptotic effectors, termed caspases, not only execute apoptosis, but are also directly involved in the generation of the signals required for AiP. Reactive oxygen species (ROS) play an important role for regenerative processes. Recently, it was shown in Drosophila that apoptotic caspases can mediate the generation of ROS for promoting AiP. This review summarizes and discusses these findings in the context of regenerative processes and cancer. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：74 / 82

页数：9

共 105 条

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