Stereoselective synthesis of 1,3-disubstituted hexahydro-1,4-diazepin-2-ones.

被引：5

作者：

Pohlmann, A ^{[1
]}

Guillaume, D ^{[1
]}

Quirion, JC ^{[1
]}

Husson, HP ^{[1
]}

机构：

[1] UNIV PARIS 05,CNRS,CHIM THERAPEUT LAB,FAC SCI PHARMACEUT & BIOL,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(97)01291-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diestereoselective alkylation of hydroxlactam 6 allowed the preparation of 1,3-disubstituted hexahydro-1,4-diazepin-2-one derivatives in optically pure form. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：5809 / 5810

页数：2

共 10 条

[1]

CHIARONI A, IN PRESS ACTA CRYSTA

[2]

CZAPLEWSKI C, 1994, POL J CHEM, V68, P2589

[3] NEW METHODS AND REAGENTS IN ORGANIC-SYNTHESIS .67. A GENERAL-SYNTHESIS OF DERIVATIVES OF OPTICALLY PURE 2-(1-AMINOALKYL)THIAZOLE-4-CARBOXYLIC ACIDS [J].

HAMADA, Y ;

SHIBATA, M ;

SUGIURA, T ;

KATO, S ;

SHIOIRI, T .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (07) :1252-1255

[4] PREPARATION AND PROPERTIES OF, AND REACTIONS WITH, METAL-CONTAINING HETEROCYCLES .11. PREPARATION AND PROPERTIES OF ETHANEDIYL, PROPANEDIYL, PENTANEDIYL, AND DECANEDIYL-BIS(TRIFLUOROMETHANESULFONATE) [J].

LINDNER, E ;

VONAU, G ;

EBERLE, HJ .

CHEMISCHE BERICHTE-RECUEIL, 1981, 114 (02) :810-813

[5] CONFORMATIONAL EFFECTS ON THE REGIOCHEMICAL METALATION OF C5-C-13 N-BENZYLLACTAMS [J].

MEYERS, AI ;

KUNNEN, KB ;

STILL, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (14) :4405-4407

[6] ASYMMETRIC-SYNTHESIS .30. SYNTHESIS OF 3-SUBSTITUTED PIPERIDINES FROM CHIRAL NON-RACEMIC LACTAMS [J].

MICOUIN, L ;

VAREA, T ;

RICHE, C ;

CHIARONI, A ;

QUIRION, JC ;

HUSSON, HP .

TETRAHEDRON LETTERS, 1994, 35 (16) :2529-2532

[7] Origins of diastereoselectivity in the alkylation of N-substituted lactams and amides derived from optically active aminoalcohols. [J].

Micouin, L ;

Jullian, V ;

Quirion, JC ;

Husson, HP .

TETRAHEDRON-ASYMMETRY, 1996, 7 (10) :2839-2846

[8] A trisubstituted 1,4-diazepine-3-one-based dipeptidomimetic: Conformational characterization by NMR and computer simulation [J].

Pellegrini, M ;

Weitz, IS ;

Chorev, M ;

Mierke, DF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (10) :2430-2436

[9] Efficient synthesis of conformationally constrained peptidomimetics containing 2-oxopiperazines [J].

Pohlmann, A ;

Schanen, V ;

Guillaume, D ;

Quirion, JC ;

Husson, HP .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (04) :1016-1022

[10] ASYMMETRIC-SYNTHESIS .31. SYNTHESIS OF 2-SUBSTITUTED PIPERAZINES FROM CHIRAL NON-RACEMIC LACTAMS [J].

SCHANEN, V ;

RICHE, C ;

CHIARONI, A ;

QUIRION, JC ;

HUSSON, HP .

TETRAHEDRON LETTERS, 1994, 35 (16) :2533-2536

← 1 →