Molecular logic of neocortical projection neuron specification, development and diversity

被引：609

作者：

Greig, Luciano Custo ^{[1
]}

Woodworth, Mollie B. ^{[1
]}

Galazo, Maria J. ^{[1
]}

Padmanabhan, Hari ^{[1
]}

Macklis, Jeffrey D. ^{[1
]}

机构：

[1] Harvard Univ, Cambridge, MA 02138 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2013年 / 14卷 / 11期

基金：

美国国家卫生研究院;

关键词：

DEVELOPING CEREBRAL-CORTEX; HEREDITARY SPASTIC PARAPLEGIA; CORTICOSPINAL MOTOR-NEURONS; PRIMARY LATERAL SCLEROSIS; SUBTYPE-SPECIFIC GENES; EMBRYONIC STEM-CELLS; CORTICAL-NEURONS; IN-VIVO; SUBVENTRICULAR ZONE; PYRAMIDAL NEURONS;

D O I：

10.1038/nrn3586

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of neuronal subtypes generated during development under precise molecular regulation. In recent years, several key controls over the specification and differentiation of neocortical projection neurons have been identified. This work provides substantial insight into the 'molecular logic' underlying cortical development and increasingly supports a model in which individual progenitor-stage and postmitotic regulators are embedded within highly interconnected networks that gate sequential developmental decisions. Here, we provide an integrative account of the molecular controls that direct the progressive development and delineation of subtype and area identity of neocortical projection neurons.

引用

页码：755 / 769

页数：15

共 147 条

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