Decreased Regional Homogeneity in Patients With Acute Mild Traumatic Brain Injury A Resting-State fMRI Study

被引：27

作者：

Zhan, Jie ^{[1
]}

Gao, Lei ^{[1
]}

Zhou, Fuqing ^{[1
]}

Kuang, Hongmei ^{[1
]}

Zhao, Jing ^{[1
]}

Wang, Siyong ^{[1
]}

He, Laichang ^{[1
]}

Zeng, Xianjun ^{[1
]}

Gong, Honghan ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 1, Dept Radiol, Nanchang City 330006, Jiangxi, Peoples R China

来源：

JOURNAL OF NERVOUS AND MENTAL DISEASE | 2015年 / 203卷 / 10期

关键词：

Acute brain injuries; mTBI; functional MRI; resting-state; regional homogeneity; DEFAULT-MODE NETWORK; MINI-MENTAL-STATE; WORKING-MEMORY; SALIENCE NETWORK; FUNCTIONAL CONNECTIVITY; MOTOR CORTEX; DISEASE; ABNORMALITIES; CONCUSSION; DISRUPTION;

D O I：

10.1097/NMD.0000000000000368

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mild traumatic brain injury (mTBI) is characterized by structural disconnection and large-scale neural network dysfunction in the resting state. However, little is known concerning the intrinsic changes in local spontaneous brain activity in patients with mTBI. The aim of the current study was to assess regional synchronization in acute mTBI patients. Fifteen acute mTBI patients and 15 sex-, age-, and education-matched healthy controls (HCs) were studied. We used the regional homogeneity (ReHo) method to map local connectivity across the whole brain and performed a two-sample t-test between the two groups. Compared with HCs, patients with acute mTBI showed significantly decreased ReHo in the left insula, left precentral/postcentral gyrus, and left supramarginal gyrus (p < 0.05, AlphaSim corrected). The ReHo index of the left insula showed a positive correlation with the Mini-Mental State Examination (MMSE) scores across all acute mTBI patients (p < 0.05, uncorrected). The ReHo method may provide an objective biomarker for evaluating the functional abnormity of mTBI in the acute setting.

引用

页码：786 / 791

页数：6

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