Developments in the Identification of Glycan Biomarkers for the Detection of Cancer

被引：116
作者：
Ruhaak, L. Renee [1 ]
Miyamoto, Suzanne [2 ]
Lebrilla, Carlito B. [1 ]
机构：
[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
[2] Univ Calif Davis, Div Hematol & Oncol, Ctr Comprehens Canc, Sacramento, CA 95817 USA
来源：
MOLECULAR & CELLULAR PROTEOMICS | 2013年 / 12卷 / 04期
基金：
美国国家卫生研究院;
关键词：
N-LINKED GLYCANS; ASSISTED-LASER-DESORPTION/IONIZATION; CHROMATOGRAPHY-MASS SPECTROMETRY; HIGH-THROUGHPUT ANALYSIS; ACUTE-PHASE PROTEINS; OVARIAN-CANCER; LIQUID-CHROMATOGRAPHY; POTENTIAL BIOMARKERS; SAMPLE PREPARATION; O-GLYCOSYLATION;
D O I：
10.1074/mcp.R112.026799
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use. Molecular & Cellular Proteomics 12: 10.1074/mcp.R112.026799, 846-855, 2013.
引用
收藏
页码：846 / 855
页数：10
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