Vesicular self-assembly of a helical peptide in water

被引：62
|
作者：
Kimura, S [1 ]
Kim, DH
Sugiyama, J
Imanishi, Y
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Sakyo Ku, Kyoto 6068501, Japan
[2] Kyoto Univ, Inst Wood Sci, Kyoto 6110011, Japan
[3] Nara Inst Sci & Technol, Nara 6300101, Japan
来源：
LANGMUIR | 1999年 / 15卷 / 13期
关键词：
D O I：
10.1021/la981673m
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The formation of a molecular assembly composed of a naturally occurring peptide with a helical structure was investigated. Gramicidin A, a 15-mer peptide antibiotic, was conjugated with poly(ethylene glycol) (PEG, average molecular weight 600). This peptide conjugate formed vesicles with an unilamellar membrane in water as shown by frozen-hydrated/cryo-transmission electron microscopy (cryo-TEM) observations. The peptide fragment adopted an antiparallel double-helix conformation. The vesicles of the gramicidin conjugate encapsulating PEG showed much greater stability than encapsulation by dimyristoylphosphatidylcholine liposomes with respect to resistance to collapse upon detergent addition. Since the peptide membrane core is constituted of the secondary structured units, the peptide vesicles (named peptosomes) may be advantageous to functional membranes due to their highly regular structure.
引用
收藏
页码：4461 / 4463
页数：3
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