New Xymedon Analogues for Stimulation of Posttraumatic Regeneration of the Spinal Cord in Rats

被引：9

作者：

Povysheva, T. V. ^{[1
]}

Semenov, V. E. ^{[2
]}

Galyametdinova, I. V. ^{[2
]}

Reznik, V. S. ^{[2
]}

Knni, K. S. ^{[1
]}

Kolesnikov, P. E. ^{[1
]}

Chelyshev, Yu. A. ^{[1
]}

机构：

[1] Kazan State Med Univ, Dept Histol Cytol & Embryol, Minist Hlth Russian Federat, Kazan, Russia

[2] Russian Acad Sci, AE Arbuzov Inst Organ & Phys Chem, Lab Nucleobases Chem, Kazan Sci Ctr, Kazan, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 162卷 / 02期

基金：

俄罗斯科学基金会;

关键词：

spinal cord injury; pyrimidine; xymedon; SCIATIC-NERVE REGENERATION; PYRIMIDINE COMPOUND; MS-818; SURVIVAL; INJURY; MS-430;

D O I：

10.1007/s10517-016-3580-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Effect of systemic administration of synthetic pyrimidine derivatives, xymedon and compounds 29D and 34D, was studied in rats with experimental dosed contusion spinal cord injury. Xymedon promoted recovery of motor function after injury. Compounds 29D and 34D more effectively restored the parameters of open-field and Rotarod tests in comparison with xymedon. Compound 29D more effectively than xymedon maintained the number of Olig2(+) oligodendrocytes in the corticospinal tract and NG2 cells in all investigated areas of the white matter. In the group treated with compound 34D, the differences in the number of NG2(+) cells were revealed only in the anterior funiculi, where the number of these glial cells was 2-fold higher than in the xymedon-treated group. Obtained results suggest that the studied xymedon analogs, compounds 29D and 34D, can exert their therapeutic action through different molecular and cellular pathways.

引用

页码：220 / 224

页数：5

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