Sonic hedgehog as a chemoattractant for adult NPCs

被引：21

作者：

Hor, Catherine Hong Huan ^{[1
]}

Tang, Bor Luen ^{[1
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117595, Singapore

来源：

CELL ADHESION & MIGRATION | 2010年 / 4卷 / 01期

关键词：

cell migration; neural progenitor cells (NPCs); rostral migratory stream (RMS); sonic hedgehog (Shh); subventricular zone (SVZ);

D O I：

10.4161/cam.4.1.9914

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The developmental morphogen Sonic hedgehog (Shh) is well known for its role in modulating the proliferation and survival of neural progenitor cells in the developing mouse brain. A recent report now showed that Shh could regulate the migration of neuroblast in the adult subventricular zone (SVZ) along the rostral migratory stream (RMS) to the olfactory bulb, by functioning as a chemoattractant. Functions of Shh in regulating the migration and survival of neural progenitor cells in the adult central nervous system are suggestive of its potential roles in neural regeneration and CNS oncogenesis.

引用

页码：1 / 3

页数：3

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