Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors

被引:45
|
作者
Sardi, Natalia Fantin [1 ]
Tobaldini, Glaucia [1 ]
Morais, Rosana Nogueira [1 ]
Fischer, Luana [1 ]
机构
[1] Univ Fed Parana, Dept Physiol, Div Biol Sci, BR-81531990 Curitiba, Parana, Brazil
关键词
Pain; Nociception; Sleep loss; Sleep disturbances; Caffeine; Mesolimbic system; Nucleus accumbens shell; Nucleus accumbens core; C-FOS EXPRESSION; VENTRAL STRIATUM; CLINICAL-TRIALS; PAIN; RATS; WAKEFULNESS; RECOVERY; MODEL; METABOLITES; DISTURBANCE;
D O I
10.1097/j.pain.0000000000001066
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Sleep disorders increase pain sensitivity and the risk of developing painful conditions; however, the underlying mechanisms are poorly understood. It has been suggested that nucleus accumbens (NAc) influences sleep-wake cycle by means of a balance between adenosine activity at A(2A) receptors and dopamine activity at D-2 receptors. Because the NAc also plays an important role in pain modulation, we hypothesized that the NAc and its A(2A) and D-2 receptors mediate the pronociceptive effect of rapid eye movement (REM) sleep deprivation (SD). We found that 24 hours of REM-SD induced an intense pronociceptive effect in Wistar rats, which decreases progressively over a sleep rebound period. Although the level of fecal glucocorticoid metabolites increased with SD within group, it did not differ between sleep-deprived group and control group, indicating a stress response with similar magnitude between groups. The pronociceptive effect of REM-SD was prevented by excitotoxic lesion (N-Methyl-D-aspartate, 5.5 mu g) of NAc and reverted by its acute blockade (Qx-31 4, 2%). The administration of an A(2A) receptor antagonist (SCH-58261, 7 ng) or a D-2 receptor agonist (piribedil, 6 mu g) into the NAc increased home cage activity and blocked the pronociceptive effect of REM-SD. Complementarily, an A(2A) receptor agonist (CGS-21680, 24 ng) impaired the reversal of the pronociceptive effect and decreased home cage activity, as it did a D-2 receptor antagonist (raclopride, 5 mu g). Rapid eye movement SD did not affect the expression of c-Fos protein in NAc. These data suggest that SD increases pain by increasing NAc adenosinergic A(2A) activity and by decreasing NAc dopaminergic D-2 activity.
引用
收藏
页码:75 / 84
页数:10
相关论文
共 50 条
  • [21] Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens.: Effects of chronic caffeine exposure
    Quarta, D
    Ferré, S
    Solinas, M
    You, ZB
    Hockemeyer, J
    Popoli, P
    Goldberg, SR
    JOURNAL OF NEUROCHEMISTRY, 2004, 88 (05) : 1151 - 1158
  • [22] Orexin A induced antinociception in the ventral tegmental area involves D1 and D2 receptors in the nucleus accumbens
    Yazdi-Ravandi, Saeid
    Razavi, Yasaman
    Haghparast, Amir
    Goudarzvand, Mandi
    Haghparast, Abbas
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2014, 126 : 1 - 6
  • [23] Dopamine D2 receptors in the bed nucleus of the stria terminalis modulate alcohol-related behaviors
    Pati, Dipanwita
    Taxier, Lisa R.
    Xia, Mengfan
    Lee, Sophia I.
    Conley, Sara Y.
    Sides, Tori
    Boyt, Kristen M.
    Hunker, Avery C.
    Zweifel, Larry S.
    Kash, Thomas L.
    ADDICTION NEUROSCIENCE, 2024, 11
  • [24] Orexin-A up-regulates dopamine D2 receptor and mRNA in the nucleus accumbens Shell
    Sandra Morales-Mulia
    Víctor Manuel Magdaleno-Madrigal
    Humberto Nicolini
    Alma Genis-Mendoza
    Marcela Morales-Mulia
    Molecular Biology Reports, 2020, 47 : 9689 - 9697
  • [25] Examination of the role of dopamine D2 and adrenergic α2 receptors in resurgence of food seeking
    Pyszczynski, Adam D.
    Shahan, Timothy A.
    BEHAVIOURAL BRAIN RESEARCH, 2014, 271 : 122 - 128
  • [26] Orexin-A up-regulates dopamine D2 receptor and mRNA in the nucleus accumbens Shell
    Morales-Mulia, Sandra
    Magdaleno-Madrigal, Victor Manuel
    Nicolini, Humberto
    Genis-Mendoza, Alma
    Morales-Mulia, Marcela
    MOLECULAR BIOLOGY REPORTS, 2020, 47 (12) : 9689 - 9697
  • [27] Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
    Bonaventura, Jordi
    Navarro, Gemma
    Casado-Anguera, Veronica
    Azdad, Karima
    Rea, William
    Moreno, Estefania
    Brugarolas, Marc
    Mallol, Josefa
    Canela, Enric I.
    Lluis, Carme
    Cortes, Antoni
    Volkow, Nora D.
    Schiffmann, Serge N.
    Ferre, Sergi
    Casado, Vicent
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (27) : E3609 - E3618
  • [28] Association between striatal dopamine D2/D3 receptors and brain activation during visual attention: effects of sleep deprivation
    Tomasi, D.
    Wang, G-J
    Volkow, N. D.
    TRANSLATIONAL PSYCHIATRY, 2016, 6 : e828 - e828
  • [29] Striatal dopamine D2 receptors in modulation of pain in humans:: a review
    Hagelberg, N
    Jääskelainen, SK
    Martikainen, IK
    Mansikka, H
    Forssell, H
    Harry, SF
    Hietala, G
    Pertovaara, A
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 500 (1-3) : 187 - 192
  • [30] Sleep Deprivation Increased Dopamine D2 Receptor Expression through Downregulation of miR-9
    Wen, Ruojian
    Chen, Xiaoqing
    Huang, Dan
    Chen, Minjie
    Liu, Yuwei
    2015 7TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY IN MEDICINE AND EDUCATION (ITME), 2015, : 239 - 242