Jozimine A ('Dimeric' dioncophylline A), a non-natural michellamine analog with high antimalarial activity

被引：33

作者：

Bringmann, G ^{[1
]}

Saeb, W ^{[1
]}

Koppler, D ^{[1
]}

Francois, G ^{[1
]}

机构：

[1] INST TROP MED PRINCE LEOPOLD,B-2000 ANTWERP,BELGIUM

来源：

TETRAHEDRON | 1996年 / 52卷 / 42期

关键词：

D O I：

10.1016/0040-4020(96)00812-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of jozimine A, the first non-natural dimer of a naturally occurring monomeric naphthylisoquinoline alkaloid, is described, starting from dioncophylline A, as isolated from Triphyophyllum peltatum, resp. prepared by total synthesis. It is the first dimeric naphthylisoquinoline alkaloid that displays distinct antimalarial activity (IC50 = 0.075 mu g/ml) against asexual erythrocytic stages of Plasmodium falciparum, which even exceeds the activity of its monomeric precursor, dioncophylline A (IC50 = 1.44 mu g/ml), and thus constitutes a novel type of antimalarial quateraryls. Copyright (C) 1996 Elsevier Science Ltd

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页码：13409 / 13418

页数：10

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