Chalcones as Promising Lead Compounds on Cancer Therapy

被引：72

作者：

Leon-Gonzalez, Antonio J. ^{[1
,2
]}

Acero, Nuria ^{[3
]}

Munoz-Mingarro, Dolores ^{[3
]}

Navarro, Inmaculada ^{[4
]}

Martin-Cordero, Carmen ^{[1
]}

机构：

[1] Univ Seville, Fac Farm, Dept Farmacol, E-41012 Seville, Spain

[2] Univ Strasbourg, Fac Pharm, Lab Biophoton & Pharmacol, UMR 7213,CNRS, Illkirch Graffenstaden, France

[3] Univ San Pablo CEU, Dept Biol, Fac Farm & Med, Madrid 28668, Spain

[4] Univ Seville, Fac Farm, Dept Quim Fis, E-41012 Seville, Spain

来源：

CURRENT MEDICINAL CHEMISTRY | 2015年 / 22卷 / 30期

关键词：

Apoptosis; cancer; chalcone; chemoprevention; flavonoid; synthesis; tubulin; CELL-CYCLE ARREST; NF-KAPPA-B; ISOLIQUIRITIGENIN INDUCES APOPTOSIS; DEATH-RECEPTOR; 5; BIOLOGICAL EVALUATION; FLAVOKAWAIN B; NATURAL-PRODUCTS; NITRIC-OXIDE; IN-VITRO; CHEMOPREVENTIVE ACTIVITY;

D O I：

10.2174/0929867322666150729114829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chalcones constitute a group of phenolic compounds that command an increasing interest on cancer research. Natural chalcones are widespread through the plant kingdom. The most abundant and investigated chalcones are isoliquiritigenin, flavokawain and xanthohumol, which are present in the Fabaceae, Piperaceae, Cannabaceae, and Moraceae families. These chalcones have been shown to be promising lead antitumor-chemopreventive drugs by three different activities: antioxidants, cytotoxic and apoptosis inducers. In the recent years, SAR (structure-activity relationship) has contributed towards the improvement of anticancer properties of chalcones by substituting aryl rings and introducing heterocyclic moieties. This review summarizes the anticancer activities shown by natural chalcones and the SAR and describes how different chemical moiety modifications could lead them to be therapeutically useful in the treatment of cancer.

引用

页码：3407 / 3425

页数：19

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