Central sensitisation in visceral pain disorders

被引:52
作者
Moshiree, B.
Zhou, Q.
D Price, D.
Verne, G. N.
机构
[1] Univ Florida, Coll Med, Div Gastroenterol Hepatol & Nutr, Dept Med, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Dent, Gainesville, FL 32610 USA
[3] Univ Florida, Coll Med, Dept Oral & Maxillofacial Surg, Gainesville, FL 32610 USA
[4] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA
关键词
D O I
10.1136/gut.2005.078287
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The concepts of visceral hyperalgesia and visceral hypersensitivity have been examined in a variety of functional gastrointestinal disorders (FGIDs). Although the pathophysiological mechanisms of pain and hypersensitivity in these disorders are still not well understood, exciting new developments in research have been made in the study of the brain-gut interactions involved in the FGIDs
引用
收藏
页码:905 / 908
页数:4
相关论文
共 33 条
[1]   SELECTIVE DYSFUNCTION OF MECHANOSENSITIVE INTESTINAL AFFERENTS IN IRRITABLE-BOWEL-SYNDROME [J].
ACCARINO, AM ;
AZPIROZ, F ;
MALAGELADA, JR .
GASTROENTEROLOGY, 1995, 108 (03) :636-643
[2]   A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development [J].
Al-Chaer, ED ;
Kawasaki, M ;
Pasricha, PJ .
GASTROENTEROLOGY, 2000, 119 (05) :1276-1285
[3]   Pain hypersensitivity in patients with functional gastrointestinal disorders - A gastrointestinal-specific defect or a general systemic condition? [J].
Bouin, M ;
Meunier, P ;
Riberdy-Poitras, M ;
Poitras, P .
DIGESTIVE DISEASES AND SCIENCES, 2001, 46 (11) :2542-2548
[4]   Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia [J].
Chang, L ;
Mayer, EA ;
Johnson, T ;
FitzGerald, LZ ;
Naliboff, B .
PAIN, 2000, 84 (2-3) :297-307
[5]   PATIENTS WITH IRRITABLE-BOWEL-SYNDROME HAVE GREATER PAIN TOLERANCE THAN NORMAL SUBJECTS [J].
COOK, IJ ;
VANEEDEN, A ;
COLLINS, SM .
GASTROENTEROLOGY, 1987, 93 (04) :727-733
[6]   Multimodal pain stimulations in patients with grade B oesophagitis [J].
Drewes, A. M. ;
Reddy, H. ;
Pedersen, J. ;
Funch-Jensen, P. ;
Gregersen, H. ;
Arendt-Nielsen, L. .
GUT, 2006, 55 (07) :926-932
[7]   Pathobiology of visceral pain: Molecular mechanisms and therapeutic implications - IV. Visceral afferent contributions to the pathobiology of visceral pain [J].
Gebhart, GF .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 278 (06) :G834-G838
[8]   Quantitative assessment of neuropathic pain. [J].
Greenspan J.D. .
Current Pain and Headache Reports, 2001, 5 (2) :107-113
[9]   The role of psychological and biological factors in postinfective gut dysfunction [J].
Gwee, KA ;
Leong, YL ;
Graham, C ;
McKendrick, MW ;
Collins, SM ;
Walters, SJ ;
Underwood, JE ;
Read, NW .
GUT, 1999, 44 (03) :400-406
[10]   PATTERNS OF INCREASED BRAIN ACTIVITY INDICATIVE OF PAIN IN A RAT MODEL OF PERIPHERAL MONONEUROPATHY [J].
MAO, JR ;
MAYER, DJ ;
PRICE, DD .
JOURNAL OF NEUROSCIENCE, 1993, 13 (06) :2689-2702