Direct Synthesis of α-Alkoxy Ketones by Oxidative C-O Bond Formation

被引：15

作者：

Yu, Hui ^{[1
]}

Xu, Yilan ^{[1
]}

Fang, Yan ^{[1
]}

Dong, Rui ^{[1
]}

机构：

[1] Tongji Univ, Dept Chem, Siping Rd 1239, Shanghai 200092, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 31期

关键词：

Synthetic methods; Ketones; C-O bond formation; Oxidation; Oxidative coupling; LEWIS-ACID CONDITIONS; N-TOSYLHYDRAZONES; METAL-FREE; TRANSFER HYDROGENATION; ASYMMETRIC-SYNTHESIS; INSERTION REACTIONS; CONSTRUCTION; TBAI/TBHP; CATALYST; ACCESS;

D O I：

10.1002/ejoc.201600723

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method to prepare alpha-alkoxy ketones has been developed by oxidative coupling of aryl methyl ketones and alcohols. With aqueous tert-butyl hydroperoxide (6.0 equiv.) as the oxidant, tetrabutylammonium iodide (20 mol-%) as the catalyst, and TsNHNH2 (1.0 equiv.) as the additive, ketones underwent direct alkoxylation to give alpha-methoxy or alpha-ethoxy ketones in moderate to good yields.

引用

页码：5257 / 5262

页数：6

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