The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness

被引：53

作者：

Moraitis, Andreas G. ^{[1
]}

Block, Thaddeus ^{[1
,2
]}

Dat Nguyen ^{[1
]}

Belanoff, Joseph K. ^{[1
,2
]}

机构：

[1] Corcept Therapeut, 149 Commonwealth, Menlo Pk, CA 94025 USA

[2] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2017年 / 165卷

关键词：

Glucocorticoid receptor; Polymorphism; Metabolic syndrome; Psychiatric disorders; HPA-AXIS; FUNCTIONAL POLYMORPHISM; PSYCHOTIC DEPRESSION; MAJOR DEPRESSION; BODY-COMPOSITION; IN-VIVO; C-JUN; GENE; RISK; ASSOCIATION;

D O I：

10.1016/j.jsbmb.2016.03.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucocorticoids (GCs) are involved in a large number of the physiological changes associated with metabolic syndrome and certain psychiatric illness. Although significance is often given to the concentration of GC, its biological action is determined by the activation of intracellular GC receptors (GR). Genetic polymorphisms of the GR and the large array of GR related cofactors can directly or indirectly affect the pathophysiology and evolution of these conditions. This review will discuss the effects of GR mutations on metabolic syndrome and psychotic depression. (C) 2016 The Authors. Published by Elsevier Ltd.

引用

页码：114 / 120

页数：7

共 72 条

[1] ENHANCED STEROID RESPONSE OF A HUMAN GLUCOCORTICOID RECEPTOR SPLICE VARIANT [J].

Baker, Aaron C. ;

Green, Tajia L. ;

Chew, Victoria W. ;

Tung, Kelly ;

Amini, Amir ;

Lim, Debora ;

Cho, Kiho ;

Greenhalgh, David G. .

SHOCK, 2012, 38 (01) :11-17

[2] Associations of glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms on fat mass and fat mass distribution in prepubertal obese children [J].

Barat, Pascal ;

Corcuff, Jean-Benoit ;

Tauber, Maite ;

Moisan, Marie-Pierre .

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2012, 68 (04) :645-650

[3] The HPA - immune axis and the immunomodulatory actions of glucocorticoics in the brain [J].

Bellavance, Marc-Andre ;

Rivest, Serge .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[4] Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults [J].

Binder, Elisabeth B. ;

Bradley, Rebekah G. ;

Liu, Wei ;

Epstein, Michael P. ;

Deveau, Todd C. ;

Mercer, Kristina B. ;

Tang, Yilang ;

Gillespie, Charles F. ;

Heim, Christine M. ;

Nemeroff, Charles B. ;

Schwartz, Ann C. ;

Cubells, Joseph F. ;

Ressler, Kerry J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (11) :1291-1305

[5] Efficacy and Safety of Mifepristone for the Treatment of Psychotic Depression [J].

Blasey, Christine M. ;

Block, Thaddeus S. ;

Belanoff, Joseph K. ;

Roe, Robert L. .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2011, 31 (04) :436-440

[6] Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression [J].

Brouwer, Jantien P. ;

Appelhof, Bente C. ;

van Rossum, Elisabeth F. C. ;

Koper, Jan W. ;

Fliers, Eric ;

Huyser, Jochanan ;

Schene, Aart H. ;

Tijssen, Jan G. P. ;

Van Dyck, Richard ;

Lamberts, Steven W. J. ;

Wiersinga, Wilmar M. ;

Hoogendijk, Witte J. G. .

PSYCHONEUROENDOCRINOLOGY, 2006, 31 (10) :1154-1163

[7]

Ciechanover A, 2000, BIOESSAYS, V22, P442, DOI 10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO

[8]

2-Q

[9] DNA recognition by nuclear receptors [J].

Claessens, F ;

Gewirth, DT .

ESSAYS IN BIOCHEMISTRY: NUCLEAR RECEPTOR SUPERFAMILY, 2004, 40 :59-72

[10]

Clement K, 1996, INT J OBESITY, V20, P507

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