Synthesis of 7,8,9-trisubstituted dihydropurine derivatives via a 'tert-Amino Effect' cyclization

被引：28

作者：

Che, Xin ^{[1
]}

Zheng, Lianyou ^{[1
]}

Dang, Qun ^{[1
]}

Bai, Xu ^{[1
]}

机构：

[1] Jilin Univ, Ctr Combinatorial Chem & Drug Discovery, Changchun 130012, Peoples R China

来源：

SYNLETT | 2008年 / 15期

基金：

中国国家自然科学基金;

关键词：

tert-amino effect; dihydropurine; hydrogen transfer; imines; cyclizations;

D O I：

10.1055/s-2008-1078212

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7,8,9-Trisubstituted dihydropurine derivatives were prepared from 5-amino-4-(N,N-disubstituted)aminopyrimidines and aromatic aldehydes via a cascade of reactions. The key transformation for the reaction is a [1,6]-hydrogen shift due to a 'tert-amino effect'.

引用

页码：2373 / 2375

页数：3

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