Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila

被引：30

作者：

Chen, Sidi ^{[1
]}

Spletter, Maria ^{[2
,3
]}

Ni, Xiaochun ^{[1
,4
,5
]}

White, Kevin P. ^{[1
,4
,5
]}

Luo, Liqun ^{[2
,3
]}

Long, Manyuan ^{[1
]}

机构：

[1] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[2] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[4] Univ Chicago, Inst Genom & Syst Biol, Chicago, IL 60637 USA

[5] Argonne Natl Lab, Chicago, IL 60637 USA

来源：

CELL REPORTS | 2012年 / 1卷 / 02期

基金：

美国国家科学基金会;

关键词：

COCKROACH MUSHROOM BODIES; NERVOUS-SYSTEM; DEPENDENT SELECTION; INSERTION SCREEN; ANTENNAL LOBE; EXPRESSION; MELANOGASTER; ODOR; BODY; POLYMORPHISM;

D O I：

10.1016/j.celrep.2011.12.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The evolution of the brain and behavior are coupled puzzles. The genetic bases for brain evolution are widely debated, yet whether newly evolved genes impact the evolution of the brain and behavior is vaguely understood. Here, we show that during recent evolution in Drosophila, new genes have frequently acquired neuronal expression, particularly in the mushroom bodies. Evolutionary signatures combined with expression profiling showed that natural selection influenced the evolution of young genes expressed in the brain, notably in mushroom bodies. Case analyses showed that two young retrogenes are expressed in the olfactory circuit and facilitate foraging behavior. Comparative behavioral analysis revealed divergence in foraging behavior between species. Our data suggest that during adaptive evolution, new genes gain expression in specific brain structures and evolve new functions in neural circuits, which might contribute to the phenotypic evolution of animal behavior.

引用

页码：118 / 132

页数：15

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