Palladium-Catalyzed C3 Acylation of Benzofurans and Benzothiophenes with Aromatic Aldehydes by Cross-Dehydrogenative Coupling Reactions

被引：26

作者：

Zhao, Jincan ^{[1
]}

Fang, Hong ^{[1
]}

Xie, Chen ^{[1
]}

Han, Jianlin ^{[1
,2
]}

Li, Guigen ^{[2
,3
]}

Pan, Yi ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat, Nanjing 210093, Jiangsu, Peoples R China

[2] Nanjing Univ, Inst Chem & BioMed Sci, Nanjing 210093, Jiangsu, Peoples R China

[3] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2卷 / 12期

基金：

中国国家自然科学基金;

关键词：

benzofurans; benzothiophenes; CH activation; cross-dehydrogenative coupling; palladium; ALPHA-OXOCARBOXYLIC ACIDS; H BOND ACTIVATION; DECARBOXYLATIVE ORTHO-ACYLATION; TERT-BUTYL HYDROPEROXIDE; O-METHYL KETOXIMES; TOLUENE DERIVATIVES; ACYL RADICALS; ACETANILIDES; 2-ARYLPYRIDINES; COMPLEXES;

D O I：

10.1002/ajoc.201300208

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-3Pd: A direct C3 acylation of benzofurans and benzothiophenes by sp2 C-H activation catalyzed by palladium acetate is reported. tert-Butyl hydroperoxide (TBHP) is used as the oxidant and aldehydes are used as aroyl sources to give the desired products in excellent yields. This cross-dehydrogenative coupling reaction provides practical access to 3-acylbenzofurans and 3-acylbenzothiophenes. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1044 / 1047

页数：4

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