Palladium-Catalyzed C3 Acylation of Benzofurans and Benzothiophenes with Aromatic Aldehydes by Cross-Dehydrogenative Coupling Reactions

被引：26
作者：
Zhao, Jincan [1 ]
Fang, Hong [1 ]
Xie, Chen [1 ]
Han, Jianlin [1 ,2 ]
Li, Guigen [2 ,3 ]
Pan, Yi [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat, Nanjing 210093, Jiangsu, Peoples R China
[2] Nanjing Univ, Inst Chem & BioMed Sci, Nanjing 210093, Jiangsu, Peoples R China
[3] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2卷 / 12期
基金：
中国国家自然科学基金;
关键词：
benzofurans; benzothiophenes; CH activation; cross-dehydrogenative coupling; palladium; ALPHA-OXOCARBOXYLIC ACIDS; H BOND ACTIVATION; DECARBOXYLATIVE ORTHO-ACYLATION; TERT-BUTYL HYDROPEROXIDE; O-METHYL KETOXIMES; TOLUENE DERIVATIVES; ACYL RADICALS; ACETANILIDES; 2-ARYLPYRIDINES; COMPLEXES;
D O I：
10.1002/ajoc.201300208
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
C-3Pd: A direct C3 acylation of benzofurans and benzothiophenes by sp2 C-H activation catalyzed by palladium acetate is reported. tert-Butyl hydroperoxide (TBHP) is used as the oxidant and aldehydes are used as aroyl sources to give the desired products in excellent yields. This cross-dehydrogenative coupling reaction provides practical access to 3-acylbenzofurans and 3-acylbenzothiophenes. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1044 / 1047
页数：4
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