An invitation to T and more: Notch signaling in lymphopoiesis

被引:117
作者
Allman, D
Punt, JA
Izon, DJ
Aster, JC
Pear, WS [1 ]
机构
[1] Univ Penn, Med Ctr, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Med Ctr, Inst Med & Engn, Philadelphia, PA 19104 USA
[3] Univ Penn, Med Ctr, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[4] Haverford Coll, Dept Biol, Haverford, PA 19041 USA
[5] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1016/S0092-8674(02)00689-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell fate decisions in metazoans are regulated by Notch signals. During lymphoid development, Notch influences a series of cell fate decisions involving multipotent progenitors. This review focuses on current views and lingering uncertainties about Notch function in lymphoid cells.
引用
收藏
页码:S1 / S11
页数:11
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