Biocompatibility of sol-gel hydroxyapatite-titania composite and bilayer coatings

被引：59
|
作者：
Sidane, D. [1 ]
Rammal, H. [2 ]
Beljebbar, A. [3 ]
Gangloff, S. C. [2 ]
Chicot, D. [4 ]
Velard, F. [2 ]
Khireddine, H. [1 ]
Montagne, A. [5 ]
Kerdjoudj, H. [2 ]
机构：
[1] Univ Bejaia, Fac Technol, LGE, Bejaia 06000, Algeria
[2] Univ Reims, SFR CAP Sante FED 4231, Equipe Accueil Biomat & Inflammat Site Osseux 469, 1 Ave Marechal Juin, F-51100 Reims, France
[3] Univ Reims, SFR CAP Sante FED 4231, UMR CNRS 7369, Equipe MeDIAN Biophoton & Technol Sante,UFR Pharm, 51 Rue Cognacq Jay, F-51096 Reims, France
[4] Univ Lille, LML, FRE 3723, F-59000 Lille, France
[5] Arts & Metiers Paris Tech, MSMP, 8,Blvd Louis 14, F-59046 Lille, France
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 72卷
关键词：
Stainless steel 316L; Surface coating; Hydroxyapatite; Titania; Stem cells; Biocompatibility; 316L STAINLESS-STEEL; MECHANICAL-PROPERTIES; ORTHOPEDIC IMPLANTS; ELASTIC-MODULUS; CORROSION; SUBSTRATE; BEHAVIOR; CULTURE; LAYER; INDENTATION;
D O I：
10.1016/j.msec.2016.11.129
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Titania-Hydroxyapatite (TiO2/HAP) reinforced coatings are proposed to enhance the bioactivity and corrosion resistance of 316L stainless steel (316L SS). Herein, spin- and dip-coating sol-gel processes were investigated to construct two kinds of coatings: TiO2/HAP composite and TiO2/HAP bilayer. Physicochemical characterization highlighted the bioactivity response of the TiO2/HAP composite once incubated in physiological conditions for 7 days whereas the TiO2/HAP bilayer showed instability and dissolution. Biological analysis revealed a failure in human stem cells adhesion on TiO2/HAP bilayer whereas on TiO2/HAP composite the presence of polygonal shaped cells, possessing good behaviour attested a good biocompatibility of the composite coating. Finally, TiO2/HAP composite with hardness up to 0.6 GPa and elastic modulus up to 18 GPa, showed an increased corrosion resistance of 316L SS. In conclusion, the user-friendly sol-gel processes led to bioactive TiO2/HAP composite buildup suitable for biomedical applications. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：650 / 658
页数：9
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