Modeling the Dynamics of Bivalent Histone Modifications

被引：9
作者：
Ku, Wai Lim [1 ,2 ]
Girvan, Michelle [1 ,2 ,3 ]
Yuan, Guo-Cheng [4 ,5 ]
Sorrentino, Francesco [6 ]
Ott, Edward [1 ,2 ,7 ]
机构：
[1] Univ Maryland, Dept Phys, College Pk, MD 20742 USA
[2] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA
[3] Univ Maryland, Inst Phys Sci & Technol, College Pk, MD 20742 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[5] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA
[6] Univ New Mexico, Dept Mech Engn, Albuquerque, NM 87131 USA
[7] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA
来源：
PLOS ONE | 2013年 / 8卷 / 11期
基金：
美国国家卫生研究院;
关键词：
EMBRYONIC STEM-CELLS; GENOME; MEMORY; DIFFERENTIATION; DEMETHYLASES; PLURIPOTENT; PROPAGATION; METHYLATION; INHERITANCE; ACTIVATION;
D O I：
10.1371/journal.pone.0077944
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that bivalent domains play an important role in stem cell differentiation, but the underlying mechanisms remain unclear. Here we formulate a mathematical model to investigate the dynamic properties of histone modification patterns. We then illustrate that our modeling framework can be used to capture key features of experimentally observed combinatorial chromatin states.
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页数：13
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