Targeting microRNA in hematologic malignancies

被引：9
作者：
Han, Zhen [1 ,4 ]
Rosen, Steven T. [2 ,4 ]
Querfeld, Christiane [1 ,2 ,3 ,4 ]
机构：
[1] City Hope Natl Med Ctr, Div Dermatol, Duarte, CA USA
[2] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA
[3] City Hope Natl Med Ctr, Dept Pathol, Duarte, CA USA
[4] City Hope Natl Med Ctr, Beckman Res Inst, 1500 Duarte Rd, Duarte, CA 91010 USA
来源：
CURRENT OPINION IN ONCOLOGY | 2020年 / 32卷 / 05期
基金：
美国国家卫生研究院;
关键词：
biogenesis; biomarker; epigenetics; hematologic malignancies; microRNA; microRNA-therapeutics; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HEALTH-ORGANIZATION CLASSIFICATION; DOWN-REGULATION; EXPRESSION PROFILES; MULTIPLE-MYELOMA; MIRNA EXPRESSION; GENE-EXPRESSION; THERAPEUTIC APPLICATION; CIRCULATING MICRORNAS;
D O I：
10.1097/CCO.0000000000000657
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose of review MiRNAs are critical regulators for gene expression. Numerous studies have revealed how miRNAs contribute to the pathogenesis of hematologic malignancies. Recent findings The identification of novel miRNA regulatory factors and pathways crucial for miRNA dysregulation has been linked to hematologic malignancies. miRNA expression profiling has shown their potential to predict outcomes and treatment responses. Recently, targeting miRNA biogenesis or pathways has become a promising therapeutic strategy with recent miRNA-therapeutics being developed. We provide a comprehensive overview of the role of miRNAs for diagnosis, prognosis, and therapeutic potential in hematologic malignancies.
引用
收藏
页码：535 / 544
页数：10
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