Impact of Gender and Age on Rapid Eye Movement-Related Obstructive Sleep Apnea: A Clinical Study of 3234 Japanese OSA Patients

被引：30

作者：

Mano, Mamiko ^{[1
,2
]}

Hoshino, Tetsuro ^{[1
,2
]}

Sasanabe, Ryujiro ^{[1
,2
]}

Murotani, Kenta ^{[3
]}

Nomura, Atsuhiko ^{[1
,2
]}

Hori, Reiko ^{[1
,2
]}

Konishi, Noriyuki ^{[1
,2
]}

Baku, Masayo ^{[1
,2
]}

Shiomi, Toshiaki ^{[1
,2
]}

机构：

[1] Aichi Med Univ Hosp, Dept Sleep Med, 1-1 Nagakute, Nagakute, Aichi 4801195, Japan

[2] Aichi Med Univ Hosp, Sleep Disorders Ctr, 1-1 Nagakute, Nagakute, Aichi 4801195, Japan

[3] Kurume Univ, Grad Sch Med, Biostat Ctr, 67 Asahimachi, Kurume, Fukuoka 8300011, Japan

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2019年 / 16卷 / 06期

关键词：

obstructive sleep apnea; rapid eye movement-related obstructive sleep apnea; female sex hormone; POSITIVE AIRWAY PRESSURE; STROKE; WOMEN; ADHERENCE; FEATURES; DISEASE;

D O I：

10.3390/ijerph16061068

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Rapid eye movement (REM)-related obstructive sleep apnea (OSA) is characterized by apnea and hypopnea events due to airway collapse occurring predominantly or exclusively during REM sleep. Previous studies have reported that REM-related OSA occurs more commonly in women and younger individuals. However, external validity of this tendency has not been confirmed in a large clinical sample. The objective of this study was to evaluate the effect of gender and age on REM-related OSA after adjustment for several covariates based on their established clinical relationships to gender difference in OSA. A total of 3234 Japanese patients with OSA were enrolled in this study. We confirmed that female sex is an important risk factor for REM-related OSA, as reported by previous studies. Moreover, we showed that women aged over 50 years were at a greater risk than those aged under 50 years. These results suggest that hormonal changes in women might play an important role in REM-related OSA and might reflect its unknown pathophysiological characteristics.

引用

页数：9

共 31 条

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