Vitamin D and Lung Infection

被引：14

作者：

Cantorna, Margherita T. ^{[1
]}

机构：

[1] Penn State Univ, Dept Vet & Biomed Sci, Ctr Immunol & Infect Dis, University Pk, PA 16802 USA

来源：

INFECTION AND IMMUNITY | 2016年 / 84卷 / 11期

关键词：

T-CELLS; HOST-RESISTANCE; D-3; TUBERCULOSIS; RESPONSES; PROMOTES; ANALOGS; MICE;

D O I：

10.1128/IAI.00679-16

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Available data suggest that vitamin D plays a role in controlling inflammation in the lungs. However, to date vitamin D-induced production of cathelicidin has not been shown to have an effect on the burden of either viruses or bacteria. Future work should continue to determine the effects of vitamin D-regulated mechanisms in the lung and the possible role of cathelicidin against different pulmonary pathogens in vivo.

引用

收藏

页码：3094 / 3096

页数：3

相关论文

共 25 条

[1] METABOLISM OF 25-HYDROXYVITAMIN-D3 BY CULTURED PULMONARY ALVEOLAR MACROPHAGES IN SARCOIDOSIS [J].

ADAMS, JS ;

SHARMA, OP ;

GACAD, MA ;

SINGER, FR .

JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (05) :1856-1860

[2] Vitamin D Deficiency Promotes Epithelial Barrier Dysfunction and Intestinal Inflammation [J].

Assa, Amit ;

Vong, Linda ;

Pinnell, Lee J. ;

Avitzur, Naama ;

Johnson-Henry, Kathene C. ;

Sherman, Philip M. .

JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (08) :1296-1305

[3] Unique features of human cathelicidin LL-37 [J].

Bandurska, Katarzyna ;

Berdowska, Agnieszka ;

Barczynska-Felusiak, Renata ;

Krupa, Piotr .

BIOFACTORS, 2015, 41 (05) :289-300

[4] Could Vitamin D Have a Potential Anti-Inflammatory and Anti-Infective Role in Bronchiectasis? [J].

Bartley, Jim ;

Garrett, Jeff ;

Grant, Cameron C. ;

Camargo, Carlos A., Jr. .

CURRENT INFECTIOUS DISEASE REPORTS, 2013, 15 (02) :148-157

[5] Vitamin D and host resistance to infection? Putting the cart in front of the horse [J].

Bruce, Danny ;

Ooi, Jot Hui ;

Yu, Sanhong ;

Cantorna, Margherita T. .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 235 (08) :921-927

[6] Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice [J].

Bruce, Danny ;

Whitcomb, James P. ;

August, Avery ;

McDowell, Mary Ann ;

Cantorna, Margherita T. .

INTERNATIONAL IMMUNOLOGY, 2009, 21 (02) :113-122

[7] Vitamin D and 1,25(OH)2D Regulation of T cells [J].

Cantorna, Margherita T. ;

Snyder, Lindsay ;

Lin, Yang-Ding ;

Yang, Linlin .

NUTRIENTS, 2015, 7 (04) :3011-3021

[8] The vitamin D receptor turns off chronically activated T cells [J].

Cantorna, Margherita T. ;

Waddell, Amanda .

STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES I, 2014, 1317 :70-75

[9] 1,25-dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density [J].

Cantorna, MT ;

Hullett, DA ;

Redaelli, C ;

Brandt, CR ;

Humpal-Winter, J ;

Sollinger, HW ;

DeLuca, HF .

TRANSPLANTATION, 1998, 66 (07) :828-831

[10] Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment [J].

Coussens, Anna K. ;

Wilkinson, Robert J. ;

Hanifa, Yasmeen ;

Nikolayevskyy, Vladyslav ;

Elkington, Paul T. ;

Islam, Kamrul ;

Timms, Peter M. ;

Venton, Timothy R. ;

Bothamley, Graham H. ;

Packe, Geoffrey E. ;

Darmalingam, Mathina ;

Davidson, Robert N. ;

Milburn, Heather J. ;

Baker, Lucy V. ;

Barker, Richard D. ;

Mein, Charles A. ;

Bhaw-Rosun, Leena ;

Nuamah, Rosamond ;

Young, Douglas B. ;

Drobniewski, Francis A. ;

Griffiths, Christopher J. ;

Martineau, Adrian R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (38) :15449-15454