Protein transduction technology

被引：433

作者：

Wadia, JS ^{[1
]}

Dowdy, SF ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Howard Hughes Med Inst, Dept Cell & Mol Biol, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0958-1669(02)00284-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular delivery of macromolecules remains problematic because of the bioavailability restriction imposed by the cell membrane. Recent studies on protein transduction domains have circumvented this barrier, however, and have resulted in the delivery of peptides, full-length proteins, iron beads, liposomes, and radioactive isotopes into cells in culture and animal models in vivo.

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收藏

页码：52 / 56

页数：5

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