The Regulatory Role of IL-10 in Neurodegenerative Diseases

被引：156

作者：

Porro, Chiara ^{[1
]}

Cianciulli, Antonia ^{[2
]}

Panaro, Maria Antonietta ^{[2
]}

机构：

[1] Univ Foggia, Dept Clin & Expt Med, I-71122 Foggia, Italy

[2] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, I-70125 Bari, Italy

来源：

BIOMOLECULES | 2020年 / 10卷 / 07期

关键词：

IL-10; neurodegeneration; neuroinflammation; microglia; signaling; INTERLEUKIN-10 PROMOTER POLYMORPHISMS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; AUTOIMMUNE ENCEPHALOMYELITIS; INFLAMMATORY CYTOKINES; GENE POLYMORPHISMS; INHIBITORY FACTOR; DENDRITIC CELLS; TNF-ALPHA;

D O I：

10.3390/biom10071017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the neurodegeneration associated with neuroinflammation, in diseases such as Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Alzheimer's Disease, and Parkinson's Disease, focusing on the contribution of this cytokine not only in terms of protective action, but also as possibly responsible for clinical worsening. The knowledge of this double face of the same coin, regarding the biological role of the IL-10, could aid the development of targeted therapies useful for limiting neurodegenerative processes.

引用

页码：1 / 15

页数：15

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