Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells

被引：7

作者：

Chae, Hee-Sung ^{[2
]}

Khiev, Piseth ^{[3
]}

Lee, Hyeong-Kyu ^{[2
,3
]}

Oh, Sei-Ryang ^{[2
]}

Chin, Young-Won ^{[1
]}

机构：

[1] Dongguk Univ Seoul, Coll Pharm, Seoul 100715, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Biotherapeut Res Inst, Immune Modulator Res Ctr, Cheongwon, South Korea

[3] Univ Sci & Technol, Taejon, South Korea

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2012年 / 34卷 / 04期

关键词：

Cinnamomum cambodianum; interleukin-6; prostaglandin D-2; leukotriene C-4; degranulation; bone marrow-derived mast cell; KAPPA-B ACTIVATION; HIGH-AFFINITY; TNF-ALPHA; DEGRANULATION; MOUSE; SECRETION; RECEPTOR; LINE; IGG;

D O I：

10.3109/08923973.2011.648267

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cinnamomum cambodianum has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of C. cambodianum was evaluated for its effect on allergic mediators, including prostaglandin D-2 (PGD(2)), leukotriene C-4 (LTC4), beta-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extract inhibited the production of interleukin-6, PGD(2) and LTC4, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of C. cambodianum in the treatment of allergy.

引用

页码：639 / 644

页数：6

共 23 条

[1]

ALBER G, 1991, J BIOL CHEM, V266, P22613

[2] Human mast cell cytokines [J].

Bradding, P .

CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 (01) :13-19

[3] Chemical constituents of two Mollinedia species [J].

Claros, BMG ;

da Silva, AJR ;

Vasconcellos, MLAA ;

de Brito, APP ;

Leitao, GG .

PHYTOCHEMISTRY, 2000, 55 (07) :859-862

[4] Immunomodulatory mast cells: negative, as well as positive, regulators of immunity [J].

Galli, Stephen J. ;

Grimbaldeston, Michele ;

Tsai, Mindy .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :478-U14

[5]

Hide I, 1997, J IMMUNOL, V159, P2932

[6] Inhibition of TNF-α and IL-6 production by aucubin through blockade of NF-κB activation in RBL-2H3 mast cells [J].

Jeong, HJ ;

Koo, HN ;

Na, HJ ;

Kim, MS ;

Hong, SH ;

Eom, JW ;

Kim, KS ;

Shin, TY ;

Kim, HM .

CYTOKINE, 2002, 18 (05) :252-259

[7] Histamine in allergic inflammation and immune modulation [J].

Jutel, M ;

Blaser, K ;

Akdis, CA .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2005, 137 (01) :82-92

[8] IL-6 signal transduction and its physiological roles: the signal orchestration model [J].

Kamimura, D ;

Ishihara, K ;

Hirano, T .

REVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL 149, 2004, 149 :1-38

[9] Involvement of mitogen-activated protein kinase and NF-κB activation in Ca2+-induced IL-8 production in human mast cells [J].

Kim, MS ;

Lim, WK ;

Park, RK ;

Shin, T ;

Yoo, YH ;

Hong, SH ;

An, NH ;

Kim, HM .

CYTOKINE, 2005, 32 (05) :226-233

[10] Prolonged Culture of Mast Cells with High-Glucose Medium Enhances the FcεRI-Mediated Degranulation Response and Leukotriene C4 Production [J].

Kitahata, Yuko ;

Nunomura, Satoshi ;

Terui, Tadashi ;

Ra, Chisei .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2010, 152 :22-31

← 1 2 3 →