Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

被引：2

作者：

Scaparrotta, Alessandra ^{[1
]}

Attanasi, Marina ^{[1
]}

Petrosino, Marianna I. ^{[1
]}

Di Filippo, Paola ^{[1
]}

Di Pillo, Sabrina ^{[1
]}

Chiarelli, Francesco ^{[1
]}

机构：

[1] Univ G dAnnunzio, Dept Pediat, I-66013 Chieti, Italy

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2015年 / 9卷

关键词：

Timothy grass pollen extract; allergic rhinitis; Grazax; efficacy; safety; compliance; RANDOMIZED CONTROLLED-TRIAL; TERM CLINICAL-EFFICACY; SUBLINGUAL IMMUNOTHERAPY; DOUBLE-BLIND; INDUCED RHINOCONJUNCTIVITIS; IMMUNOLOGICAL CHANGES; SEASONAL RHINOCONJUNCTIVITIS; COST-EFFECTIVENESS; PHLEUM-PRATENSE; CELL-ACTIVATION;

D O I：

10.2147/DDDT.S70432

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Allergic rhinitis is one of the most common diseases of adult and pediatric age, associated with grass pollen (GP) allergy in >50% cases, with a consistent impact on quality of life of affected patients. A grass allergen tablet, containing standardized extract derived from Timothy grass (Phleum pratense) pollen and similar to 15 mu g major allergen P. pratense (rPhl p 5), may be the future of allergen-specific immunotherapy (IT) for GP allergy. The aim of this review was to critically evaluate the role of Timothy GP extract IT for the management of allergic rhinitis. For this purpose, we have tried to analyze potential mechanisms of action at the basis of Timothy GP extract, we have reviewed efficacy studies to establish potential benefits and clinical response, and we have also evaluated safety and tolerability profiles and patient focus perspective, such as quality of life, satisfaction and acceptability, and compliance to this IT.

引用

页码：5897 / 5909

页数：12

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