One-Pot Palladium-Catalyzed Borrowing Hydrogen Synthesis of Thioethers

被引：39

作者：

Corma, Avelino ^{[1
]}

Navas, Javier ^{[1
]}

Rodenas, Tania ^{[1
]}

Sabater, Maria J. ^{[1
]}

机构：

[1] Inst Tecnol Quim UPV CSIC, Valencia 46022, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 51期

关键词：

heterogeneous catalysis; hydrogen transfer; palladium; synthetic methods; thioethers; EFFICIENT SYNTHESIS; GOLD; OXIDATION; SULFUR; THIOLS; SULFIDES; ALDEHYDES; DERIVATIVES; SELECTIVITY; ANTAGONISTS;

D O I：

10.1002/chem.201302226

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium on magnesium oxide is able to allow a one-pot reaction to synthesize thioethers from thiols and aldehydes formed in situ from the respective alcohol by means of a borrowing hydrogen method. The reaction is initiated by dehydrogenation of the alcohol to give a palladium hydride intermediate and an aldehyde. The latter reacts with a thiol involving most probably the intermediacy of a thionium ion RCHS+R, which can be reduced in situ by the metal hydride to afford thioethers.

引用

页码：17464 / 17471

页数：8

共 70 条

[51]

OLAH GA, 1993, SYNLETT, P32

[52]

OLAH GA, 1992, SYNTHESIS-STUTTGART, P465

[53] Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4′-substituted 4-aminodiphenyl sulfones [J].