Serum Cystatin C Is Related to Pulse Wave Velocity Even in Subjects with Normal Serum Creatinine

被引：24

作者：

Song, Sang Heon ^{[1
,2
]}

Kwak, Ihm Soo ^{[1
,2
]}

Kim, Young Joo ^{[2
,3
]}

Lee, Hee Sun ^{[1
,2
]}

Rhee, Harin ^{[1
,2
]}

Lee, Dong Won ^{[1
,2
]}

Kang, Yang Ho ^{[1
,2
]}

Kim, Seong-Jang ^{[2
,4
]}

机构：

[1] Pusan Natl Univ Hosp, Dept Internal Med, Pusan 602739, South Korea

[2] Pusan Natl Univ Hosp, Med Res Inst, Pusan 602739, South Korea

[3] Pusan Natl Univ Hosp, Dept Family Med, Pusan 602739, South Korea

[4] Pusan Natl Univ Hosp, Dept Nucl Med, Pusan 602739, South Korea

来源：

HYPERTENSION RESEARCH | 2008年 / 31卷 / 10期

关键词：

cystatin C; pulse wave velocity; arterial stiffness;

D O I：

10.1291/hypres.31.1895

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We hypothesized that serum cystatin C can be a more predictable marker of arterial stiffness than serum creatinine and creatinine-based glomerular filtration rate (GFR). The aim of this study is to evaluate whether serum cystatin C is related to arterial stiffness independently of serum creatinine in subjects for whom serum creatinine is normal. A total of 2,018 individuals (1,120 males, 898 females) were enrolled. Mean brachial-ankle pulse wave velocity (baPWV) was used as a marker of arterial stiffness and sex-specific analysis was performed. A positive relationship between baPWV and serum cystatin C (Y=1109.0548+329.9102X, r(2)=0.056, p < 0.001) was found in males. Stepwise multivariate regression analysis in males showed that age, waist circumference, heart rate, cystatin C level, triglycericle level, and fasting glucose were independent contributors to baPWV. In females, a positive relationship between baPWV and serum cystatin C (Y=1035.7828+402.2970X, r(2)=0.090, p < 0.001) was found. Stepwise multivariate regression analysis showed that age, heart rate, cystatin C level, fasting glucose and insulin level were independent contributors to baPWV. Age, heart rate, fasting glucose and serum cystatin C were the significant variables in both genders that contributed to baPWV. In conclusion, this study confirmed that serum cystatin C was related to pulse wave velocity even in subjects with normal serum creatinine. This finding suggested that cystatin C could be a more predictable marker of arterial stiffness than serum creatinine and creatinine-based GFR. (Hypertens Res 2008; 31: 1895-1902)

引用

页码：1895 / 1902

页数：8

共 24 条

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