Helicobacter pylori research: historical insights and future directions

被引：92

作者：

Fock, Kwong Ming ^{[1
]}

Graham, David Y. ^{[2
]}

Malfertheiner, Peter ^{[3
]}

机构：

[1] Changi Gen Hosp, Singapore 529889, Singapore

[2] Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA

[3] Otto Von Guericke Univ, D-39120 Magdeburg, Germany

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2013年 / 10卷 / 08期

基金：

英国医学研究理事会;

关键词：

PACIFIC CONSENSUS GUIDELINES; UNIDENTIFIED CURVED BACILLI; GASTRIC-CANCER; TRIPLE-THERAPY; BACTERIAL MICROBIOTA; SEQUENTIAL THERAPY; INFECTION; ERADICATION; VACCINES; CLARITHROMYCIN;

D O I：

10.1038/nrgastro.2013.96

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori leads to chronic gastritis, peptic ulcer disease and gastric cancer. With increasing issues of antibiotic resistance and changing epidemiology of this pathogen, new approaches are needed for effective management. In 1984, Dr Barry Marshall and Dr Robin Warren reported the association of Helicobacter pylori with peptic ulcers in The Lancet-a discovery that earned them the Nobel prize in Physiology or Medicine in 2005-but what progress have we made since then? Here, we have invited three international experts to give their insights into the advances in H. pylori research over the past 30 years and where research should be focused in the future.

引用

页码：495 / 500

页数：6

共 45 条

[1] Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines [J].