MET and Small-Cell Lung Cancer

被引：34

作者：

Gelsomino, Francesco ^{[1
]}

Rossi, Giulio ^{[2
]}

Tiseo, Marcello ^{[3
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori, Med Oncol Unit 1, Dept Med Oncol, Via G Venezian 1, I-20133 Milan, Italy

[2] Azienda Osped Univ Policlin, Operat Unit Pathol, Via Pozzo 71, I-41124 Modena, Italy

[3] Azienda Osped Univ, Viale Gramsci 14, Med Oncol Unit, I-43126 Parma, Italy

来源：

CANCERS | 2014年 / 6卷 / 04期

关键词：

c-MET; small-cell lung cancer; mutations; c-MET signaling pathway; HEPATOCYTE GROWTH-FACTOR; FACTOR SCATTER FACTOR; RECEPTOR TYROSINE KINASE; NF-KAPPA-B; C-MET; COPY NUMBER; MESENCHYMAL TRANSITION; THORACIC RADIOTHERAPY; MUTATIONAL ANALYSIS; SIGNALING PATHWAY;

D O I：

10.3390/cancers6042100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small-cell lung cancer (SCLC) is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC.

引用

页码：2100 / 2115

页数：16

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