Hydroxyapatite as a new solid support for the Knoevenagel reaction in heterogeneous media without solvent

被引：117

作者：

Sebti, S ^{[1
]}

Tahir, R ^{[1
]}

Nazih, R ^{[1
]}

Saber, A ^{[1
]}

Boulaajaj, S ^{[1
]}

机构：

[1] Univ Hassan II, Fac Sci Ben M Sik, Lab Chim Organ Appl & Catalyse, Casablanca, Morocco

来源：

APPLIED CATALYSIS A-GENERAL | 2002年 / 228卷 / 1-2期

关键词：

hydroxyapatite; activation by ammonium; activation by water; solid support; heterogeneous catalysis; Knoevenagel reaction;

D O I：

10.1016/S0926-860X(01)00961-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Knoevenagel condensation is easily carried out without a solvent at room temperature using hydroxyapatite (HAP). Activation by water and benzyltriethylammonium chloride (BTEAC) has also been investigated. When used with water and ammonium salt, hydroxyapatite is an excellent solid support for the Knoevenagel condensation, leading to excellent yields in a few minutes. Taking into account environmental and economical considerations, the handling of hydroxyapatite used here presents many advantages such as easier separation and recovery from the reaction mixture and thus, enhanced recycling possibilities, which are now well established in fine organic synthesis. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：155 / 159

页数：5

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