DMAP-Catalyzed Regel-Type Direct C-2 (Hetero)Aroylation of Oxazoles and Thiazoles Derivatives with Acid Chlorides

被引：26
作者：
Lassalas, Pierrik
Marsais, Francis
Hoarau, Christophe [1 ]
机构：
[1] Normandie Univ, COBRA, UMR 6014, F-76821 Mont St Aignan, France
来源：
SYNLETT | 2013年 / 24卷 / 17期
关键词：
acylation; azoles; C-H functionalization; heterocycles; metal-free; regioselectivity; 5-MEMBERED N-HETEROCYCLES; C-H ACTIVATION; DIRECT ARYLATION; HETEROAROMATIC-COMPOUNDS; CARBONYL-COMPOUNDS; BOND FORMATION; ARYL HALIDES; BENGAZOLE-A; POTENT; FUNCTIONALIZATION;
D O I：
10.1055/s-0033-1339858
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Regel-type transition-metal-free direct C-2 aroylation of (benzo)oxazoles, (benzo)thiazoles and 1,3,4-oxadiazoles with acid chlorides catalyzed by N,N-dimethyl-4-aminopyridine (DMAP) is described. This methodology is effective with several aroyl and heteroaroyl chlorides affording the corresponding 2-ketoazoles in moderate to excellent yields.
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收藏
页码：2233 / 2240
页数：8
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