Single molecule nanometronome

被引：46

作者：

Buranachai, C

McKinney, SA

Ha, T ^{[1
]}

机构：

[1] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Phys, Urbana, IL 61801 USA

[3] Howard Hughes Med Inst, Urbana, IL 61801 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 03期

关键词：

D O I：

10.1021/nl052492p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the sticky end. Since the device displays clearly distinguishable responses even with a single base pair difference, it may lead to a single molecule sensor of minute sequence differences of a target DNA.

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页码：496 / 500

页数：5

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